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Matchday 4 - 03 December 2008
| Group | Home | Away | ||
|---|---|---|---|---|
| A | Manchester City | 20:45 | PSG | More » |
| A | Twente | 20:45 | Schalke | More » |
| B | Metalist | 20:45 | Olympiacos | More » |
| B | Hertha | 20:45 | Galatasaray | More » |
| C | Standard | 20:45 | Sampdoria | More » |
| C | Sevilla | 20:45 | Partizan | More » |
| D | Spartak Moskva | 18:00 | NEC | More » |
| D | Udinese | 18:00 | Dinamo Zagreb | More » |
Matchday 4 - 04 December 2008
| Group | Home | Away | ||
|---|---|---|---|---|
| E | Wolfsburg | 20:45 | Portsmouth | More » |
| E | Heerenveen | 20:45 | Braga | More » |
| F | Slavia | 20:45 | Hamburg | More » |
| F | Aston Villa | 20:45 | Žilina | More » |
| G | Valencia | 20:45 | Club Brugge | More » |
| G | København | 20:45 | Rosenborg | More » |
| H | Lech | 20:45 | Deportivo | More » |
| H | Nancy | 20:45 | CSKA Moskva | More » |
