Matchday 1 - Thursday 17 September 2009
| Grp | ||||
|---|---|---|---|---|
| A | AFC Ajax | 0 - 0 | FC Timişoara | More » |
| A | NK Dinamo Zagreb | 0 - 2 | RSC Anderlecht | More » |
| B | LOSC Lille Métropole | 1 - 1 | Valencia CF | More » |
| B | Genoa CFC | 2 - 0 | SK Slavia Praha | More » |
| C | SK Rapid Wien | 3 - 0 | Hamburger SV | More » |
| C | Hapoel Tel-Aviv FC | 2 - 1 | Celtic FC | More » |
| D | Hertha BSC Berlin | 1 - 1 | FK Ventspils | More » |
| D | SC Heerenveen | 2 - 3 | Sporting Clube de Portugal | More » |
| E | FC Basel 1893 | 2 - 0 | AS Roma | More » |
| E | PFC CSKA Sofia | 1 - 1 | Fulham FC | More » |
| F | SK Sturm Graz | 0 - 1 | FC Dinamo 1948 Bucureşti | More » |
| F | Panathinaikos FC | 1 - 3 | Galatasaray AŞ | More » |
| G | S.S. Lazio | 1 - 2 | FC Salzburg | More » |
| G | Villarreal CF | 1 - 0 | PFC Levski Sofia | More » |
| H | FC Steaua Bucureşti | 0 - 0 | FC Sheriff | More » |
| H | Fenerbahçe SK | 1 - 2 | FC Twente | More » |
| I | SL Benfica | 2 - 0 | FC BATE Borisov | More » |
| I | Everton FC | 4 - 0 | AEK Athens FC | More » |
| J | Club Brugge KV | 1 - 4 | FC Shakhtar Donetsk | More » |
| J | FK Partizan | 2 - 3 | Toulouse FC | More » |
| K | AC Sparta Praha | 2 - 2 | PSV Eindhoven | More » |
| K | CFR 1907 Cluj | 2 - 0 | FC København | More » |
| L | CD Nacional | 2 - 3 | Werder Bremen | More » |
| L | Athletic Club | 3 - 0 | FK Austria Wien | More » |
