Matchday 3 - Thursday 22 October 2009
| Grp | ||||
|---|---|---|---|---|
| A | AFC Ajax | 2 - 1 | NK Dinamo Zagreb | More » |
| A | FC Timişoara | 0 - 0 | RSC Anderlecht | More » |
| B | Valencia CF | 1 - 1 | SK Slavia Praha | More » |
| B | LOSC Lille Métropole | 3 - 0 | Genoa CFC | More » |
| C | Celtic FC | 0 - 1 | Hamburger SV | More » |
| C | Hapoel Tel-Aviv FC | 5 - 1 | SK Rapid Wien | More » |
| D | Hertha BSC Berlin | 0 - 1 | SC Heerenveen | More » |
| D | FK Ventspils | 1 - 2 | Sporting Clube de Portugal | More » |
| E | Fulham FC | 1 - 1 | AS Roma | More » |
| E | PFC CSKA Sofia | 0 - 2 | FC Basel 1893 | More » |
| F | Galatasaray AŞ | 4 - 1 | FC Dinamo 1948 Bucureşti | More » |
| F | Panathinaikos FC | 1 - 0 | SK Sturm Graz | More » |
| G | FC Salzburg | 1 - 0 | PFC Levski Sofia | More » |
| G | S.S. Lazio | 2 - 1 | Villarreal CF | More » |
| H | FC Sheriff | 2 - 0 | FC Twente | More » |
| H | FC Steaua Bucureşti | 0 - 1 | Fenerbahçe SK | More » |
| I | SL Benfica | 5 - 0 | Everton | More » |
| I | FC BATE Borisov | 2 - 1 | AEK Athens FC | More » |
| J | Club Brugge KV | 2 - 0 | FK Partizan | More » |
| J | FC Shakhtar Donetsk | 4 - 0 | Toulouse FC | More » |
| K | PSV Eindhoven | 1 - 0 | FC København | More » |
| K | AC Sparta Praha | 2 - 0 | CFR 1907 Cluj | More » |
| L | FK Austria Wien | 2 - 2 | Werder Bremen | More » |
| L | Athletic Club | 2 - 1 | CD Nacional | More » |
