Who will prevail when Croatia host fellow unbeaten side Ukraine? Is Andrea Belotti destined to score on his return to Palermo? And might Wales give a debut to a 17-year-old forward?
Will 17-year-old Ben Woodburn make his Wales debut?
Ben Woodburn was the surprise name in the Wales squad named by Chris Coleman last week. The English-born forward made headlines in November when he became Liverpool's youngest-ever goalscorer at the age of 17 years, one month and 14 days, breaking the record set by Michael Owen in May 1997.
Woodburn, capped at Under-19 level, has since made three FA Cup starts for the Reds and could be given his senior international debut as third-placed Wales attempt to make up ground on section leaders the Republic of Ireland in Dublin.
Republic of Ireland v Wales, 20:45CET
Andrea Belotti's Palermo return
Andrea Belotti left Palermo to join Torino in August 2015 after scoring six times in his first Serie A campaign. On Friday, the 23-year-old will be back in the Sicilian city to face Albania as the leading marksman in the Italian top flight, having registered 22 goals in 26 appearances for the Granata this season.
"Belotti is always scoring – always," said Albania's Italian coach Gianni De Biasi. "He started scoring regularly last January and hasn't stopped since." Nicknamed Il Gallo (the rooster), Belotti has scored three goals in five outings for Italy.
Italy v Albania, 20:45CET
Unbeaten sides meets in Zagreb
First plays second in Group I as leaders Croatia (ten points) host Ukraine (eight). Ante Čačić's side have conceded a solitary goal to date but their defence has been decimated by injury in the lead up to Friday. Dejan Lovren (knee), Vedran Ćorluka (thigh), Šime Vrsaljko (knee) are all out and Darijo Srna retired from international football last summer. Domagoj Vida, who plays his club football in Ukraine for Dynamo Kyiv, is a doubt too.
Croatia v Ukraine, 20:45CET