Neither side have lost in the 2005/06 Premier League, and the result next Monday will decide who enters the winter break as autumn champions, with third and fourth-placed FC Chornomorets Odesa and FC Illychivets Mariupil 12 points behind second-placed Dynamo.
Shakhtar's domestic success has coincided with a fine run in European competition. They have won their opening two UEFA Cup Group G fixtures, although Mircea Lucescu's side did show signs of weakness when succumbing to second-division FC Karpaty Lviv in the Ukrainian Cup quarter-finals.
Worryingly for Dynamo, Shakhtar have conceded just five league goals all season, and they are also continuing to search for talent with Argentinian left-winger Lucas Mareque reported to have agreed a move from Argentina's CA River Plate.
Dynamo, meanwhile, are still looking for a permanent coach, although caretaker Anatoli Demianenko is doing well enough to keep the pressure off the board. They are also on course to claim the Ukrainian Cup after several big clubs bowed out in the quarter-finals.
Chornomorets and FC Dnipro Dnipropetrovsk followed Shakhtar out of the competition as Dynamo held their nerve to beat FC Metalist Kharkiv 1-0. With Oleh Gusev, Florin Cernat and Maksim Shatskikh recently returned from injury, only Goran Gavrancić's absence prevents them being at full strength.
Elsewhere, Dnipro are seeking a successor to charismatic coach Evgeniy Kucherevskiy, who left the club only then to be appointed sporting director. The 64-year-old's former assistant Vadim Tischenko was unable to stop Dnipro suffering a second consecutive UEFA Cup Group D defeat this week.
Meanwhile, Viacheslav Groznyi is in temporary charge at 15th-placed FC Metalurh Zaporizhya, while FC Arsenal Kyiv have hired Oleksandr Zavarov following the dismissal of Oleksandr Baranov after three straight losses.
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