Olympique Lyonnais will be aiming to ensure lightning strikes twice when they welcome Real Madrid CF to the Stade de Gerland for the first leg of their last-16 tie.
• Lyon eliminated Madrid from the UEFA Champions League at the same stage last season en route to the semi-finals. It was the Spanish side's third defeat at Lyon in as many visits but, with José Mourinho now at the helm, they will hope for a change of luck as they bid to progress to the quarter-finals for the first time since 2003/04.
• Mourinho got the better of Lyon on his way to winning the UEFA Champions League with FC Porto and his team should not be short on confidence after topping Group G with a tournament-best 16 points. Lyon were Group B runners-up behind FC Schalke 04, but took just one point from their final three games.
• The clubs first met in the 2005/06 UEFA Champions League group stage, Lyon prevailing 3-0 at home through goals from John Carew, Juninho Pernambucano and Sylvain Wiltord. The return finished 1-1, Carew cancelling out a Guti strike.
• Lyon retained the upper hand at the same stage in 2006/07. Fred and Tiago earned a 2-0 home victory, before the sides drew 2-2 in Spain. Mahamadou Diarra, who had lined up against the Merengues 12 months earlier, scored against his old club as Madrid retrieved a two-goal deficit.
• In last season's round of 16, Jean Makoun's 47th-minute solo effort gave Lyon a first-leg lead and although Cristiano Ronaldo levelled the aggregate scores six minutes into the return at the Santiago Bernabéu, Miralem Pjanić's 75th-minute goal sent Claude Puel's men through 2-1 on aggregate.
• The lineups for last term's meeting in France on 16 February 2010 were:
Lyon: Lloris, Réveillère, Cris, Boumsong, Cissokho, Toulalan, Govou, Makoun, Pjanić (Källström 78), Delgado (Michel Bastos 89), Lisandro (Gomis 81).
Real Madrid: Casillas, Arbeloa, Sergio Ramos, Albiol, Marcelo (Garay 46), Mahamadou Diarra, Alonso, Granero, Kaká, Higuaín (Benzema 64), Ronaldo.
• Lyon have a strong run of home form behind them in the UEFA Champions League, with seven wins and just one defeat from 11 games, including qualifying. That sole reverse was a 3-0 loss to FC Bayern München in last season's semi-finals second leg.
• Prior to last season's success against Madrid, Lyon had faced Spanish opposition twice before in the last 16, losing to FC Barcelona in 2008/09 but overcoming Real Sociedad de Fútbol in 2003/04.
• Lyon's overall home record against Spanish opponents is: W4 D2 L2.
• Madrid have already recorded home and away wins against another French side, AJ Auxerre, this season.
• The visitors, who have been eliminated in the last 16 for the past six seasons, have lost their last four two-legged contests with Ligue 1 opposition. Besides succumbing to Lyon 12 months ago, the Merengues went down to AS Monaco FC in the 2003/04 UEFA Champions League quarter-finals and prior to that suffered quarter-final elimination two seasons running against Paris Saint-Germain FC – in the 1992/93 UEFA Cup and 1993/94 UEFA Cup Winners' Cup.
• Madrid's overall away record against French opponents is: W4 D1 L6.
• Madrid won the first of their nine European Champion Clubs' Cups against French club Stade de Reims Champagne in 1955/56.
• Puel faced Spanish opposition in his first European tie as a player, losing 2-0 with Monaco at Valencia CF in the 1980/81 UEFA Cup Winners' Cup first round. Nine years later Puel was in the Monaco team that beat Real Valladolid CF on penalties in the quarter-finals of the same competition.
• As a coach, Puel suffered a 4-2 aggregate defeat by RCD Mallorca with Monaco in the 1999/2000 UEFA Cup fourth round. With LOSC Lille Métropole he enjoyed a 1-0 win against Sevilla FC in the 2004/05 UEFA Cup group stage but then suffered elimination by the same opponents in the last 16 in 2005/06.
• As Porto coach in 2003/04, Mourinho oversaw a 4-2 aggregate win against Lyon in the UEFA Champions League quarter-finals with a team including Ricardo Carvalho. Mourinho's side had earlier beaten Olympique de Marseille in the group stage and then won the final 3-0 against Monaco. Overall Mourinho has won eight and lost only one of 11 meetings with French opposition.
• This tie brings Karim Benzema back to the Gerland for the second time since his €35m switch to Madrid in 2009. Ligue 1's 20-goal top scorer in 2007/08, Benzema made 112 league appearances and scored 43 goals in five seasons for Lyon, winning four league titles.
• Kaká was in the AC Milan side that beat Lyon in the 2005/06 UEFA Champions League quarter-finals, while Ronaldo scored the only goal when Manchester United FC beat Lyon at home in the last 16 in 2007/08 to confirm a 2-1 aggregate success.
• Sami Khedira was in the VfB Stuttgart team beaten home and away by Lyon in the 2007/08 group stage.
• Pjanić was twice on the losing side with Bosnia and Herzegovina against Spain in 2010 FIFA World Cup qualifying, and then lost to Carvalho's Portugal in a subsequent play-off. He also suffered a 3-1 friendly defeat by a Germany side featuring Mesut Özil and Khedira last June.
• Kim Källström was a substitute in Sweden's 2-1 Group D loss to the Spain of Iker Casillas, Sergio Ramos and Raúl Albiol at UEFA EURO 2008.
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