The trio will know that another defeat tonight would likely spell the end of their chances. That said, they can cling to the achievement of Newcastle United FC last season, who lost their first three matches in the first group stage and still progressed.
Galatasaray and Olympiacos will meet in Istanbul in a Group D showdown of the utmost importance, not least because the section's top two, Juventus FC and Real Sociedad de Fútbol, both take 100 per cent records into their contest in Turin.
Olympiacos captain Paraskevas Antzas said: "We will have a difficult game with Galatasaray but we have come to Istanbul to get a result which we hope will help our chances of continuing in the Champions League."
In Group C, Guus Hiddink's PSV travel to AEK Athens FC, who themselves have only one point so far. Given the excellent form of AS Monaco FC and RC Deportivo La Coruña, who meet in the other group fixture, a positive performance is vital for both clubs. Hiddink said: "
This is our last chance to show what we can do and see if we can progress."
Group A is a closer affair. Leaders FC Bayern München have achieved a win and a draw so far but tonight's visitors, Olympique Lyonnais, are only one point adrift as are Celtic FC, who travel to RSC Anderlecht. The Belgian team may have just one point but are in great form as shown by eight wins from nine in domestic action.
Internazionale FC can maintain their stranglehold on Group B with a third straight victory at FC Lokomotiv Moskva. However, it remains to be seen how much upheaval has been caused by the weekend sacking of coach Héctor Cúper. Inter captain Javier Zanetti said: "We are aware of the importance of this game and we are ready to give everything." Last-placed Arsenal FC, who like Lokomotiv only have one point, have also made a long trip east, to take on second-placed FC Dynamo Kyiv.
uefa.com will provide extensive coverage of tonight's eight Matchday 3 fixtures. Along with live audio and text commentaries, there will be reaction from every match and video highlights.
©UEFA.com 1998-2015. All rights reserved.