Three sides already in the last 16 of the UEFA Champions League may be joined by several others tonight.
Rangers must win
In Group E, victory for VfB Stuttgart at home to Rangers FC would secure their progress to the knockout stage - and also ensure Manchester United FC go on, regardless of their result at Panathinaikos FC. A draw would suffice for United in the event of Rangers winning.
Zidane goes home
While Group F leaders Madrid visit Olympique de Marseille in a match that marks Zinedine Zidane's return to his hometown, FC Porto are hoping to follow the Spanish champions into the next round by beating FK Partizan. However, a draw in Belgrade will be enough for José Mourinho's men should Marseille fail to defeat Madrid.
Chelsea can progress
Chelsea FC will advance from Group G if they can overcome AC Sparta Praha at Stamford Bridge tonight. Second-placed Besiktas JK travel to S.S. Lazio knowing a win there, together with a Chelsea success, will send them through too.
Tight in Group H
The situation in Group H is less straightforward. With only 13 goals scored in eight matches - and only three goals in the four games involving AC Milan - this is by far the most miserly of the eight groups. Second faces first as AFC Ajax welcome Milan to Amsterdam, while RC Celta de Vigo take on Club Brugge KV. As ever, uefa.com will bring you live text and audio commentaries of the games together with video highlights.