With Atlético and Real Madrid set for their seventh and eighth UEFA club competition encounters in the semis, UEFA.com remembers the fixtures that took age-old rivalries to the biggest stages.
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Real Madrid 2-1 Atlético Madrid
Atlético Madrid 1-0 Real Madrid (agg: 2-2, Madrid win replay 2-1)
1958/59 European Cup semi-finals
With the away goals rule some years off, a 2-2 aggregate draw set up a 'Derbi Madrileño' play-off in Zaragoza. Madrid struck first through Alfredo Di Stéfano, Enrique Collar levelled for Atlético, then Ferenc Puskás pounced on a defensive error to drive in with his lesser-spotted right foot before half-time. It was enough to send the eventual champions to the final.
AC Milan 0-0 Internazionale Milano
Internazionale Milano 1-1 AC Milan (agg: 1-1, Milan win on away goals)
2002/03 UEFA Champions League semi-finals
Paolo Maldini played a record 56 derbies against Inter, but reckoned this the tensest of all: "A crazy mix of stress and emotion." After a goalless first leg 'at home', Milan returned to the stadium they share with Inter and took the lead through Andriy Shevchenko's away goal. Obafemi Martins replied on 83 minutes yet Inter could not muster a winner. Milan beat another Italian side, Juventus, on penalties in the final.
Chelsea 1-1 Arsenal
Arsenal 1-2 Chelsea (agg: 2-3)
2003/04 UEFA Champions League quarter-finals
A 1-1 draw at Stamford Bridge had extended Chelsea's wait for a win against their London rivals to 17 games, and when they went behind in the Highbury second leg, things looked grim. However, Frank Lampard equalised early in the second half, then set up Wayne Bridge to clinch victory. "I was mad," said Chelsea manager Claudio Ranieri, describing his feelings at full time. "I had 30 seconds of delirium."
Rapid Bucureşti 1-1 Steaua Bucureşti
Rapid Bucureşti 0-0 Steaua Bucureşti (agg: 1-1, Steaua win on away goals)
2005/06 UEFA Cup quarter-finals
Together with Dinamo Bucureşti, Steaua and Rapid are still known as 'the UEFAntastics' after their UEFA Cup exploits in 2005/06. All three graced the group stage, with Rapid and Steaua proceeding to contest a memorable quarter-final. Ultimately, Bănel Nicoliţă's away goal for Steaua in the first leg decided it – but only after a concerted Rapid barrage in the return.
Werder Bremen 0-1 Hamburg
Hamburg 2-3 Werder Bremen (agg: 3-3, Bremen win on away goals)
2008/09 UEFA Cup semi-finals
Werder were grimly hanging onto an away goals advantage at 2-1 up with eight minutes of the decider left when the ball hit some screwed-up paper, causing Michael Gravgaard to miscue a pass behind for a corner. Bremen promptly scored their third, putting the tie beyond their fierce rivals (who did albeit summon a reply). General manager Klaus Allofs snatched the paper ball at full time, saying: "This is coming with me to the Werder Bremen museum."
Sevilla 0-2 Real Betis
Real Betis 0-2 Sevilla (aet, agg: 2-2, Sevilla win 4-3 on pens)
2013/14 UEFA Europa League round of 16
"A Hollywood director could not have written a better script," said captain Ivan Rakitić after Sevilla recovered from a 2-0 home defeat to get the better of their neighbours in a second-leg shoot-out. José Antonio Reyes and Carlos Bacca were on the target in the return, and while Antonio Adán stemmed the tide there was nothing Betis's keeper could do when it went to spot kicks.
Real Madrid 4-1 Atlético Madrid (aet)
2013/14 UEFA Champions League final
"In life, and in football, you've got everything one day, then you've got nothing the next," shrugged Diego Simeone after Sergio Ramos cancelled out Diego Godín's 36th-minute header deep into second-half stoppage time in Lisbon. That was the invitation for Real Madrid to run away with the game in extra time, Gareth Bale, Marcelo and Cristiano Ronaldo all registering.
Atlético Madrid 0-0 Real Madrid
Real Madrid 1-0 Atlético Madrid (agg: 1-0)
2014/15, UEFA Champions League semi-finals
Javier Hernández's strike 88 minutes into the second leg spelled another disappointment for Atlético. "Every match is an exam for us," Real Madrid boss Carlo Ancelotti concluded. "We passed this one well." They failed the next one, however, losing out to Juventus – whom Ancelotti had coached from 1999–2001 – in the semis.
Liverpool 2-0 Manchester United
Manchester United 1-1 Liverpool (agg: 1-3)
2015/16 UEFA Europa League round of 16
"I really enjoyed it – it was a great Liverpool night," beamed manager Jürgen Klopp after Liverpool's 2-0 home success against United. If Daniel Sturridge's penalty and a Roberto Firmino goal all but settled the tie at Anfield, a fine Philippe Coutinho finish in the second leg put it beyond doubt. Anthony Martial's spot kick was scant consolation for the Red Devils.
Real Madrid 1-1 Atlético Madrid (aet, Real Madrid win 5-3 on pens)
2015/16 UEFA Champions League final
Having headed the crucial equaliser in the 2014 final, Sergio Ramos got Real Madrid off the mark in Turin, and while Yannick Carrasco subsequently levelled, Atlético were left to wonder what might have happened had Antoine Griezmann's 47th-minute penalty snuck under the crossbar. As opposite number Zinédine Zidane celebrated, Simeone again remained empty-handed. "It puts a lot of years on you," he said.