Club Atlético de Madrid 0-0 Sporting Clube de Portugal The hosts were unable to break through the Sporting rearguard despite having the numerical advantage for an hour.
Hamburger SV 3-1 RSC Anderlecht Goals from Joris Mathijsen, Ruud van Nistelrooy and captain David Jarolím earned the hosts a valuable first-leg advantage against their Belgian visitors.
LOSC Lille Métropole 1-0 Liverpool FC Rafael Benítez's side have a job to do in the second leg at Anfield after teenager Eden Hazard's late free-kick eluded Pepe Reina.
The quarter-final and semi-final draws of the UEFA Champions League and UEFA Europa League are planned for 19 March, with the media accreditation deadline passing 24 hours before the event.
Play the 2009/10 UEFA Europa League Fantasy Football game, which is presented by SEAT, to test your football knowledge and you could win a SEAT Ibiza Ecomotive.
The hosts were unable to break through the Sporting rearguard despite having the numerical advantage for an hour.