NK Dinamo Zagreb striker Sammir scored one and made another in four second-half minutes to lift the Croatian club into second place in UEFA Europa League Group D.
Dinamo came out fighting following a goalless first half, and the Brazilian forward put the visitors ahead with a calm finish before his dangerous free-kick was met by Dinamo captain Igor Bišćan to put the game beyond the hosts.
Club Brugge looked the more threatening side in the first half and Karel Geraerts should have given the home side the lead after 23 minutes. Júnior Díaz's looping free-kick found him unmarked at the far post but the defender's sliced shot only found the side netting.
Adrie Koster's outfit were foiled again five minutes before the break when a superb tackle from Adrián Calello prevented Wilfried Dalmat tapping in Dorge Kouemaha's cross.
Dinamo came out stronger after the break and were soon rewarded for their efforts. Sammir made amends for his penalty miss in Croatia last time out, racing on to a through ball in the 55th minute to slot calmly past Geert De Vlieger and into the bottom left-hand corner.
Just four minutes later, Marcos Camozzato's untidy challenge on Luis Ibáñez gave Sammir the chance to deliver a curling free-kick onto the head of Bišćan, who made no mistake from seven metres.
Club Brugge were denied a route back into the game when Ivan Kelava tipped substitute Maxime Lestienne's effort round the post, and with PAOK FC winning tonight's other fixture in Group D, Dinamo know that victory at Villarreal FC on Matchday 5 will be enough to put them in the knockout stages.