A home win would propel Sevilla FC through to the UEFA Europa League round of 32 and eliminate Estoril Praia as the top and bottom sides in Group H come together in Spain.
• Estoril's best chance of having something to play for on matchday six is to win this game and hope that FC Slovan Liberec fail to take maximum points against SC Freiburg. If Liberec do prevail, Estoril will need to win by two goals or score at least two away goals in a one-goal defeat to still be able to catch Sevilla.
• Kevin Gameiro's 77th-minute strike earned Sevilla a 2-1 win when the teams met for the first time on matchday one. It was Estoril's first European defeat, home or away, and their first encounter with Spanish opponents.
• Sevilla's 13 matches against Portuguese clubs have ended W7 D2 L4 (W4 D1 L2 at home – W3 D1 L2 in Portugal). Their only previous encounters with Portuguese sides in the group stage came at home in 2005/06 (Vitória SC, 3-1) and 2006/07 (SC Braga, 2-0); on both occasions, they went on to win the UEFA Cup.
• Sevilla are unbeaten in five European home games (W3 D2), but the last team to win a UEFA club competition away match at the Estadio Ramón Sánchez Pizjuán were Estoril's Liga rivals FC Porto, 2-1 winners in a UEFA Europa League round of 32 game on 17 February 2011.
• Sevilla have made it to this stage for the sixth time since the advent of the UEFA Cup group stage in 2004/05. They have only once failed to get through to the round of 32, in 2008/09.
• Estoril are one of four sides in the group stage who are experiencing their first season in Europe, along with CS Pandurii Târgu Jiu, Wigan Athletic FC and FC Kuban Krasnodar.
• Sevilla are one of five clubs in the group stage to have won this competition before, along with Valencia CF (2004), Eintracht Frankfurt (1980), PSV Eindhoven (1978) and fellow two-time winners Tottenham Hotspur FC (1972, 1984).
• Seville is the only city to have two representatives in this season's competition, with Sevilla's neighbours Real Betis Balompié competing in Group I.
• Hailing from a town on the coast of Portugal, Estoril are the westernmost club in this season's group stage. Estoril is 6,358km west of Karaganda, the home of the competition's easternmost representatives FC Shakhtar Karagandy, although it is 6,188km from Astana, where Shakhter play their group stage home games.
• Estoril have two players with Spanish Liga experience. Forward Javier Balboa drew twice against Sevilla while on loan from Real Madrid CF at Real Racing Club in 2006/07, and later played for FC Cartagena and Albacete Balompié, while defender Mano spent two years at Villarreal CF.
• Sevilla have plenty of Portuguese talent. Experienced goalkeeper Beto has met Estoril four times with FC Marco and Leixões SC (W1 D0 L3), twice losing away games; defender Daniel Carriço helped Sporting Clube de Portugal beat Estoril 2-1 in a 2010/11 Portuguese Cup game; wing-back Diogo Figueiras recorded home victories against Estoril with both Moreirense FC and FC Paços de Ferreira.
• Sevilla coach since January 2013, Unai Emery started out as a midfielder at Real Sociedad de Fútbol but was to play the bulk of his career in Spain's second division, switching from playing to coaching at Lorca Deportiva CF after a serious knee injury. Having led UD Almería to the top tier, he coached Valencia CF from 2008 to 2012, with his side regular European contenders during that stint. More recently he had a brief spell at FC Spartak Moskva.
• One of the most exciting coaching prospects in Portugal, Marco Silva took charge of Estoril midway through 2011/12, leading them to promotion as second division champions and then on to a European debut with a fifth-place finish the following season. A journeyman defender, the Lisbon-born coach ended his career with a six-year spell at Estoril, moving from the pitch to the bench after hanging up his boots in 2011.