Matches
11 September 2021
Panetolikos
0-0
-
Asteras
19 September 2021
Atromitos
1-2
-
Panetolikos
22 September 2021
Panetolikos
1-2
-
PAOK
26 September 2021
Lamia
2-2
-
Panetolikos
02 October 2021
Panetolikos
-
-
OFI
Match postponed
03 October 2021
Panetolikos
-
-
AEK
16 October 2021
Aris
-
-
Panetolikos
Match postponed
23 October 2021
Panetolikos
-
-
Olympiacos
Match postponed
30 October 2021
Giannina
-
-
Panetolikos
Match postponed
06 November 2021
Panetolikos
-
-
Apollon Smyrnis
Match postponed
20 November 2021
Panathinaikos
-
-
Panetolikos
27 November 2021
Volos
-
-
Panetolikos
04 December 2021
Panetolikos
-
-
Ionikos
11 December 2021
Asteras
-
-
Panetolikos
15 December 2021
Panetolikos
-
-
Atromitos
18 December 2021
PAOK
-
-
Panetolikos
05 January 2022
Panetolikos
-
-
Lamia
08 January 2022
AEK
-
-
Panetolikos
15 January 2022
OFI
-
-
Panetolikos
22 January 2022
Panetolikos
-
-
Aris
29 January 2022
Olympiacos
-
-
Panetolikos
05 February 2022
Panetolikos
-
-
Giannina
12 February 2022
Apollon Smyrnis
-
-
Panetolikos
19 February 2022
Panetolikos
-
-
Panathinaikos
26 February 2022
Panetolikos
-
-
Volos
05 March 2022
Ionikos
-
-
Panetolikos