Matches
13 August 2021
Gudja United
0-1
-
Sirens
20 August 2021
Sirens
1-1
-
Mosta
12 September 2021
Sirens
1-3
-
Hibernians
18 September 2021
Santa Lucia
1-3
-
Sirens
26 September 2021
Sirens
2-2
-
Sliema
17 October 2021
Valletta
3-1
-
Sirens
24 October 2021
Sirens
-
-
Birkirkara
30 October 2021
Hamrun
-
-
Sirens
21 November 2021
Sirens
-
-
Balzan
27 November 2021
Floriana
-
-
Sirens
04 December 2021
Sirens
-
-
Gżira
12 December 2021
Sirens
-
-
Gudja United
18 December 2021
Mosta
-
-
Sirens