Matches
12 September 2021
Olympiacos
0-0
-
Atromitos
19 September 2021
Lamia
1-2
-
Olympiacos
22 September 2021
Olympiacos
4-1
-
Apollon Smyrnis
26 September 2021
Asteras
0-2
-
Olympiacos
02 October 2021
Giannina
-
-
Olympiacos
Match postponed
03 October 2021
Olympiacos
-
-
Panathinaikos
16 October 2021
Olympiacos
-
-
PAOK
Match postponed
23 October 2021
Panetolikos
-
-
Olympiacos
Match postponed
30 October 2021
Olympiacos
-
-
Ionikos
Match postponed
06 November 2021
AEK
-
-
Olympiacos
Match postponed
20 November 2021
Olympiacos
-
-
Volos
Match postponed
27 November 2021
OFI
-
-
Olympiacos
04 December 2021
Olympiacos
-
-
Aris
11 December 2021
Atromitos
-
-
Olympiacos
15 December 2021
Olympiacos
-
-
Lamia
18 December 2021
Apollon Smyrnis
-
-
Olympiacos
05 January 2022
Olympiacos
-
-
Asteras
08 January 2022
Panathinaikos
-
-
Olympiacos
15 January 2022
Olympiacos
-
-
Giannina
22 January 2022
PAOK
-
-
Olympiacos
29 January 2022
Olympiacos
-
-
Panetolikos
05 February 2022
Ionikos
-
-
Olympiacos
12 February 2022
Olympiacos
-
-
AEK
19 February 2022
Volos
-
-
Olympiacos
26 February 2022
Olympiacos
-
-
OFI
05 March 2022
Aris
-
-
Olympiacos