Matches
11 September 2020
PAOK
1-0
-
Larissa
28 September 2020
Larissa
1-1
-
Panathinaikos
04 October 2020
Apollon Smyrnis
1-0
-
Larissa
18 October 2020
Larissa
1-3
-
Asteras
31 October 2020
Volos
1-1
-
Larissa
04 November 2020
Giannina
1-2
-
Larissa
22 November 2020
AEK
4-1
-
Larissa
28 November 2020
Larissa
0-0
-
Atromitos
02 December 2020
Larissa
0-3
-
Aris
07 December 2020
Panetolikos
2-1
-
Larissa
12 December 2020
Larissa
0-1
-
OFI
20 December 2020
Olympiacos
5-1
-
Larissa
03 January 2021
Larissa
1-1
-
PAOK
06 January 2021
Larissa
0-0
-
Giannina
10 January 2021
Panathinaikos
2-0
-
Larissa
16 January 2021
Larissa
0-1
-
Apollon Smyrnis
23 January 2021
Asteras
1-0
-
Larissa
26 January 2021
Aris
1-0
-
Larissa
30 January 2021
Larissa
0-0
-
Volos
06 February 2021
Lamia
-
-
Larissa
Match postponed
15 February 2021
Larissa
2-4
-
AEK
20 February 2021
Atromitos
1-1
-
Larissa
24 February 2021
Larissa
0-1
-
Lamia
28 February 2021
Larissa
-
-
Panetolikos
06 March 2021
OFI
-
-
Larissa
14 March 2021
Larissa
-
-
Olympiacos
20 January 2021
PAOK
5-0
-
Larissa
03 February 2021
Larissa
1-2
-
PAOK