Matches
14 August 2021
Mallorca
1-1
-
Betis
20 August 2021
Betis
1-1
-
Cádiz
28 August 2021
Betis
0-1
-
Real Madrid
13 September 2021
Granada
1-2
-
Betis
19 September 2021
Betis
2-2
-
Espanyol
23 September 2021
Osasuna
1-3
-
Betis
26 September 2021
Betis
2-0
-
Getafe
03 October 2021
Villarreal
2-0
-
Betis
18 October 2021
Alavés
-
-
Betis
24 October 2021
Betis
-
-
Rayo Vallecano
27 October 2021
Betis
-
-
Valencia
31 October 2021
Atlético
-
-
Betis
07 November 2021
Betis
-
-
Sevilla
21 November 2021
Elche
-
-
Betis
28 November 2021
Betis
-
-
Levante
05 December 2021
Barcelona
-
-
Betis
12 December 2021
Betis
-
-
Real Sociedad
19 December 2021
Athletic Club
-
-
Betis
02 January 2022
Betis
-
-
Celta
09 January 2022
Rayo Vallecano
-
-
Betis
19 January 2022
Betis
-
-
Alavés
23 January 2022
Espanyol
-
-
Betis
06 February 2022
Betis
-
-
Villarreal
13 February 2022
Levante
-
-
Betis
20 February 2022
Betis
-
-
Mallorca
27 February 2022
Sevilla
-
-
Betis
06 March 2022
Betis
-
-
Atlético
13 March 2022
Betis
-
-
Athletic Club
20 March 2022
Celta
-
-
Betis
03 April 2022
Betis
-
-
Osasuna
10 April 2022
Cádiz
-
-
Betis
17 April 2022
Real Sociedad
-
-
Betis
20 April 2022
Betis
-
-
Elche
01 May 2022
Getafe
-
-
Betis
08 May 2022
Betis
-
-
Barcelona
11 May 2022
Valencia
-
-
Betis
15 May 2022
Betis
-
-
Granada
22 May 2022
Real Madrid
-
-
Betis