Matches
24 July 2021
Shakhtar Donetsk
2-1
-
Inhulets Petrove
30 July 2021
FC Lviv
-
-
Shakhtar Donetsk
07 August 2021
Shakhtar Donetsk
-
-
Olexandriya
14 August 2021
Shakhtar Donetsk
-
-
FC Metalist 1925 Kharkiv
21 August 2021
Chornomorets Odesa
-
-
Shakhtar Donetsk
28 August 2021
Minaj
-
-
Shakhtar Donetsk
11 September 2021
Shakhtar Donetsk
-
-
Dnipro-1
18 September 2021
Mariupol
-
-
Shakhtar Donetsk
25 September 2021
Shakhtar Donetsk
-
-
NK Veres Rivne
02 October 2021
Dynamo Kyiv
-
-
Shakhtar Donetsk
16 October 2021
Shakhtar Donetsk
-
-
Zorya Luhansk
23 October 2021
Vorskla
-
-
Shakhtar Donetsk
30 October 2021
Shakhtar Donetsk
-
-
Desna
06 November 2021
Kolos Kovalivka
-
-
Shakhtar Donetsk
20 November 2021
Shakhtar Donetsk
-
-
Rukh Vynnyky
27 November 2021
Inhulets Petrove
-
-
Shakhtar Donetsk
04 December 2021
Shakhtar Donetsk
-
-
FC Lviv
11 December 2021
Olexandriya
-
-
Shakhtar Donetsk
26 February 2022
FC Metalist 1925 Kharkiv
-
-
Shakhtar Donetsk
05 March 2022
Shakhtar Donetsk
-
-
Chornomorets Odesa
12 March 2022
Shakhtar Donetsk
-
-
Minaj
19 March 2022
Dnipro-1
-
-
Shakhtar Donetsk
02 April 2022
Shakhtar Donetsk
-
-
Mariupol
09 April 2022
NK Veres Rivne
-
-
Shakhtar Donetsk
16 April 2022
Shakhtar Donetsk
-
-
Dynamo Kyiv
23 April 2022
Zorya Luhansk
-
-
Shakhtar Donetsk
30 April 2022
Shakhtar Donetsk
-
-
Vorskla
07 May 2022
Desna
-
-
Shakhtar Donetsk
14 May 2022
Shakhtar Donetsk
-
-
Kolos Kovalivka
21 May 2022
Rukh Vynnyky
-
-
Shakhtar Donetsk