Matches
18 July 2021
Spartak Subotica
1-1
-
Radnicki Niš
24 July 2021
Radnicki Niš
4-2
-
Napredak
31 July 2021
Radnik Surdulica
1-1
-
Radnicki Niš
09 August 2021
Radnicki Niš
1-2
-
Backa Topola
15 August 2021
Čukarički
0-0
-
Radnicki Niš
23 August 2021
Radnicki Niš
0-1
-
Proleter
29 August 2021
Partizan
4-0
-
Radnicki Niš
12 September 2021
Radnicki Niš
1-0
-
Voždovac
17 September 2021
Novi Pazar
2-1
-
Radnicki Niš
21 September 2021
Radnicki Niš
-
-
Metalac
Match postponed
26 September 2021
Kolubara
-
-
Radnicki Niš
02 October 2021
Vojvodina
-
-
Radnicki Niš
16 October 2021
Radnicki Niš
-
-
Radnički 1923
23 October 2021
Crvena zvezda
-
-
Radnicki Niš
31 October 2021
Radnicki Niš
-
-
Mladost Lučani
06 November 2021
Radnicki Niš
-
-
Spartak Subotica
20 November 2021
Napredak
-
-
Radnicki Niš
27 November 2021
Radnicki Niš
-
-
Radnik Surdulica
05 December 2021
Backa Topola
-
-
Radnicki Niš
11 December 2021
Radnicki Niš
-
-
Čukarički
15 December 2021
Proleter
-
-
Radnicki Niš
12 February 2022
Radnicki Niš
-
-
Partizan
19 February 2022
Voždovac
-
-
Radnicki Niš
26 February 2022
Radnicki Niš
-
-
Novi Pazar
02 March 2022
Metalac
-
-
Radnicki Niš
06 March 2022
Radnicki Niš
-
-
Kolubara
12 March 2022
Radnicki Niš
-
-
Vojvodina
19 March 2022
Radnički 1923
-
-
Radnicki Niš
02 April 2022
Radnicki Niš
-
-
Crvena zvezda
10 April 2022
Mladost Lučani
-
-
Radnicki Niš