Matches
14 August 2021
Fortuna Sittard
2-1
-
Twente
22 August 2021
Twente
1-1
-
Ajax
28 August 2021
Cambuur
2-0
-
Twente
11 September 2021
Twente
1-0
-
Utrecht
19 September 2021
Vitesse
1-4
-
Twente
23 September 2021
Twente
3-1
-
AZ Alkmaar
26 September 2021
Heerenveen
2-3
-
Twente
01 October 2021
Groningen
1-1
-
Twente
17 October 2021
Twente
1-1
-
Willem II
24 October 2021
Twente
-
-
NEC
30 October 2021
PSV
-
-
Twente
05 November 2021
Twente
-
-
Heracles
20 November 2021
Sparta
-
-
Twente
28 November 2021
Twente
-
-
Feyenoord
05 December 2021
Go Ahead Eagles
-
-
Twente
12 December 2021
Twente
-
-
RKC
18 December 2021
Zwolle
-
-
Twente
22 December 2021
Utrecht
-
-
Twente
15 January 2022
Twente
-
-
Heerenveen
22 January 2022
Willem II
-
-
Twente
05 February 2022
Twente
-
-
Vitesse
13 February 2022
Ajax
-
-
Twente
20 February 2022
Twente
-
-
Go Ahead Eagles
27 February 2022
RKC
-
-
Twente
06 March 2022
Twente
-
-
Cambuur
13 March 2022
AZ Alkmaar
-
-
Twente
20 March 2022
Twente
-
-
Zwolle
03 April 2022
Twente
-
-
PSV
10 April 2022
NEC
-
-
Twente
24 April 2022
Twente
-
-
Sparta
01 May 2022
Heracles
-
-
Twente
08 May 2022
Twente
-
-
Fortuna Sittard
11 May 2022
Twente
-
-
Groningen
15 May 2022
Feyenoord
-
-
Twente
27 October 2021
Oss
-
-
Twente