A second-half Timo Werner penalty earned the last-16 newcomers a narrow win away to last season's runners-up.
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Timo Werner's second-half spot kick gave UEFA Champions League round of 16 debutants Leipzig the edge in their tie against Tottenham, rewarding the German visitors for a bold display of attacking football.
The match at a glance
The game started at breakneck pace, Angeliño drilling against the upright inside two minutes and Werner having a shot blocked. At the other end, Steven Bergwijn was foiled by a diving Péter Gulácsi but in the main the traffic was going the other way, Werner shooting straight at Hugo Lloris when well placed.
Having failed to capitalise on their first-half pressure, Leipzig began the second period a touch more conservatively, yet they were presented with a golden opportunity 13 minutes after the restart when Konrad Laimer's advance into the box was halted by a high Ben Davies challenge. Werner held his nerve to fire past Lloris from the spot, and the goalkeeper kept his team in it moments later by denying Patrick Schick after Spurs had been sliced open again.
Tottenham struggled to find a way back into the match, although Gulácsi produced a fingertip save to touch Giovani Lo Celso's free-kick on to the post and then flicked another free-kick behind, this time from substitute Erik Lamela. Lucas Moura headed over a Davies cross in the final moments, but Spurs will need to find more cutting edge in Germany in three weeks.
Man of the Match: Hugo Lloris (Tottenham)
Gareth Southgate, UEFA technical observer: "He made three or four big saves to keep Spurs in the game."
View from the stadium: Mark Pettit, Tottenham reporter
This was the evening those Spurs injuries and lack of minutes for returning players caught up with them. Leipzig looked a well-drilled, effervescent outfit and José Mourinho will be grateful the tie is not over already given some of the chances the visitors passed up. There was a late flourish from Spurs but they will have to summon their spirit from this competition last year if they are to have any hope of overturning this deficit.
Visitors' view: James Thorogood, Leipzig reporter
Ten years ago Leipzig were playing in the fifth tier of German football. Tonight, on their Champions League knockout stage debut, they dictated proceedings with a dynamic performance against last season's finalists. A penalty was required to beat an inspired Lloris as Werner broke a four-game drought to claim a crucial away goal, which is just as valuable as the clean sheet and the experience they've gained.
José Mourinho, Tottenham manager: "The boys did everything they could. They are an amazing group with amazing guys that try everything. It's like going into a fight with a gun without bullets. If we had scored before them, the game would have been different. We have a great keeper who made two amazing saves. We tried everything we could. I thank the fans for all the support for the boys. I am not worried with the 1-0, because we can perfectly go there and win the tie."
Hugo Lloris, Man of the Match: "It's not the time to give excuses. We have to keep fighting until the end. We don't have time to think too much. We are not happy about the result but there is not much we can do about it. Let's create another story, like we did last season. Leipzig are a very, very good team with a lot of energy. We had some situations that we could have managed better. I wanted a win, but we will try to create another story."
- All seven of Werner's UEFA Champions League goals, including four this season, have come away from home
- Leipzig have stretched their unbeaten UEFA Champions League away run to five games
- This was Leipzig's first win in six away matches in European knockout ties
- Tottenham have now failed to score in three of their last 30 UEFA Champions League matches
- The London club have lost their last two home knockout matches 1-0; they recovered to beat Ajax on away goals in last season's semi-final
- This is only Mourinho's third defeat in the home first leg of a UEFA Champions League tie, in his 17th match; he lost both previous contests on aggregate, with Chelsea (2005/06) and Real Madrid (2010/11), both against Barcelona
- Aged 32 years and 211 days, Leipzig's Julian Nagelsmann became the youngest coach in a UEFA Champions League knockout match, eclipsing Schalke's Domenico Tedesco (33 years 161 days) last season
Tottenham: Lloris; Aurier, Sánchez, Alderweireld, Davies; Gedson Fernandes (Ndombélé 64), Winks; Lo Celso, Alli (Lamela 64), Bergwijn; Lucas
Leipzig: Gulácsi; Klostermann, Ampadu, Halstenberg; Mukiele, Sabitzer, Laimer, Angeliño; Nkunku (Haidara 74), Werner; Schick )9