Porto will hope to finally get the better of Liverpool at the fifth time of asking as the teams meet in the round of 16, with the Portuguese side boasting better recent knockout form.
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FC Porto have never beaten Liverpool FC in four previous attempts but boast more recent UEFA Champions League knockout experience as the teams renew acquaintance in the round of 16 first leg at the Estádio do Dragão.
• While the Portuguese side have recorded two draws and two defeats in their four games against the Merseyside club, they are in the round of 16 for the second year in a row and made the most recent of their five UEFA Champions League quarter-final appearances in 2014/15. Liverpool, by contrast, were last in this stage in 2008/09 – although they did go on to the last eight in that season.
• Porto progressed to the 2017/18 knockout rounds by finishing second in Group G, while Liverpool remained unbeaten (W3 D3) in winning Group E.
• This is one of only two round of 16 ties this season to feature two former European champions: Chelsea FC's meeting with FC Barcelona is the other.
• There have been four previous matches between the teams, all in the 21st century. Their first encounters came in the quarter-finals of Liverpool's victorious 2000/01 UEFA Cup campaign; Gérard Houllier's side drew the first leg 0-0 in Portugal before first-half goals from Danny Murphy and Michael Owen secured a 2-0 second-leg, and aggregate, victory at Anfield.
• The other matches came in the 2007/08 UEFA Champions League group stage. Dirk Kuyt's 17th-minute goal earned Liverpool a 1-1 matchday one draw at Jesualdo Ferreira's Porto, who had gone in front through Lucho González's eighth-minute penalty. The visitors played the majority of the second half with ten men following Jermaine Pennant's 58th-minute red card.
• The teams at the Estádio do Dragão on 18 September 2007 were:
Porto: Nuno, Bosingwa, João Paulo, Bruno Alves, Fucile, Lucho, Assunção, Meireles (Mariano González 64), Sektioui (Farías 64), Lisandro, Quaresma.
Liverpool: Reina, Arbeola, Hyypiä, Carragher, Finnan, Mascherano, Gerrard, Pennant, Babel (Crouch 85), Kuyt, Torres (Voronin 76).
• At Anfield, Lisandro (33) cancelled out Fernando Torres' 19th-minute opener for Rafael Benítez's Liverpool, before late goals from Torres again (78), Steven Gerrard (84pen) and Peter Crouch (87) gave the home team the points. Porto and Liverpool both went through to the last 16, the Portuguese side winning the section.
• Porto's record in the round of 16 is W3 L6, and they have won only one of their last four ties. In 2016/17, they bowed out at this stage against eventual runners-up Juventus (0-2 home, 0-1 away).
• Their overall home record against English clubs is W8 D6 L3. Their last game against Premier League visitors brought a 5-0 win against already-qualified group winners Leicester City FC on matchday six last season.
• Porto picked up six points at home in this season's group stage. The Portuguese side suffered a 3-1 loss against Beşiktaş JK on matchday one, but recovered to beat RB Leipzig by the same scoreline in their second home game before sealing second place in Group G with a 5-2 matchday six defeat of AS Monaco FC.
• Porto have won only four of their last ten home matches in European competition, also losing four.
• Porto had lost their previous three UEFA Champions League fixtures, home and away, before winning at Monaco on matchday two; they have now won three of their last eight matches in the competition.
• Last season was the third time in the last six campaigns that Porto had progressed from their group. This is the first time they have reached the round of 16 two seasons in a row since getting into the knockouts every year between 2006/07 and 2009/10.
• Porto's record in two-legged ties with English clubs is W3 L7. They have lost the last four, most recently 6-1 on aggregate to Manchester City FC in the 2011/12 UEFA Europa League round of 32 (1-2 home, 0-4 away). They have not beaten English opposition in a knockout tie since José Mourinho's side eliminated Manchester United FC in the 2003/04 UEFA Champions League round of 16 (2-1 home, 1-1 away) en route to lifting the trophy.
• Liverpool have not reached the round of 16 in nine years, their most recent tie a 5-0 win against Real Madrid CF in the 2008/09 competition (1-0 away, 4-0 home). That left them with the overall record of W4 L1 at this stage; the sole defeat came at the hands of Portuguese opponents as holders in 2005/06, SL Benfica winning 1-0 at home and 2-0 away.
• That Benfica reverse is Liverpool's only loss at home to Portuguese visitors (W6 D2).
• Liverpool's most recent trip to Portugal brought a 1-0 loss at SC Braga in the 2010/11 UEFA Europa League round of 16 first leg. That was also the aggregate score, giving Liverpool the record W5 L2 in two-legged contests against Portuguese sides.
• The Reds have the record W2 D3 L4 in Portugal; they won on each of their first two visits but have triumphed in none of their last seven trips.
• Liverpool were 7-0 winners at NK Maribor on matchday three, their club record European away victory. They have nevertheless won just three of their last 16 away games (D8 L5), having drawn 1-1 at FC Spartak Moskva in their first Group E away match and let slip a 3-0 half-time lead to draw 3-3 at Sevilla FC. Before triumphing at TSG 1899 Hoffenheim in their play-off first leg, the Merseysiders' last away success had been a 1-0 UEFA Europa League group stage win at FC Rubin Kazan on 5 November 2015.
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• Iker Casillas was in the Real Madrid team beaten by Liverpool at this stage of the 2008/09 competition. He did get the better of the Reds in the 2014/15 group stage, appearing in Madrid's 3-0 win at Anfield and 1-0 success in Spain.
• Mohamed Salah's AS Roma were knocked out of the 2016/17 UEFA Champions League by Porto, losing 4-1 on aggregate defeat in the play-offs (1-1 away, 0-3 home).
• Maxi Pereira played in Benfica's 2-1 home win against Liverpool in the 2009/10 UEFA Europa League quarter-finals first leg. He was an unused substitute in the return, a 4-1 Liverpool victory.
• Ricardo Pereira and Sérgio Oliveira were in the Portugal team that beat Emre Can's Germany 5-0 in the 2015 UEFA European Under-21 Championship semi-final; Ricardo scored the second goal.
• International team-mates:
Iker Casillas & Alberto Moreno (Spain)
Óliver Torres & Alberto Moreno (Spain Under-21s)
• James Milner scored in England's 2-2 draw against hosts Portugal in the 2003 UEFA European Under-17 Championship semi-final. Portugal won 3-2 on penalties and went on to lift the trophy.
• UEFA Champions League squad changes
In: Yordan Osório, Gonçalo Paciência, Majeed Waris
Out: João Costa, Jorge Fernandes, Hernâni, Miguel Layún, Rúben Macedo, Federico Varela
• Felipe is serving a one-match ban in the first leg; André André and Danilo will incur a suspension with their next bookings.
• Porto are unbeaten in normal time since matchday six (W12 D2), although they lost on penalties to Sporting Clube de Portugal in the Portuguese League Cup semi-finals on 24 January after a goalless draw.
• The Dragons are unbeaten in the Liga this season (W17 D4) and have not lost in 24 games (W18 D6) in all competitions, since a 3-2 reverse at RB Leipzig on matchday three. On Sunday Porto were 4-0 winners at GD Chaves, Francisco Soares scoring the first two goals.
• Soares scored his first goal of the year against Sporting, having previously found the net in a 3-0 League Cup win against Rio Ave FC in 21 December. Before Sunday, his only Liga goal this season came on 9 September.
• Porto have lost only once at home all season – 3-1 against Beşiktaş JK on matchday one; their record otherwise is W15 D2. Porto have lost only two home games since the start of 2016/17, both in the UEFA Champions League – the other was a 2-0 reverse against Juventus in last season's round of 16 first leg.
• Porto lead Sporting 1-0 after the first leg of their Portuguese Cup semi-final on 7 February. The return is on 18 April.
• Iker Casillas made his 100th Porto appearance against Sporting.
• Iván Marcano (thigh, out since 24 January), Danilo Pereira (calf, 24 January), André André (ankle, 1 February) and Vincent Aboubakar (muscle fatigue) all missed the Sporting match; none featured on Saturday.
• Porto's match at Estoril Praia on 15 January was suspended at half time for security reasons with the home side leading 1-0. The remaining 45 minutes will be played on 21 February.
• Alex Telles has eight Liga assists this season, more than any other player; Yacine Brahimi has six.
• Moussa Marega has scored 16 Liga goals this season, one more than Vincent Aboubakar; Porto have managed 53 overall.
• UEFA Champions League squad changes
In: Nathaniel Clyne, Danny Ings, Virgil van Dijk
Out: Philippe Coutinho, Jon Flanagan, Marko Grujić, Daniel Sturridge
• Emre Can serves a one-game suspension in the first leg; Alberto Moreno is a booking away from a ban.
• The Reds were unbeaten in their first nine games after matchday six (W6 D3) but then suffered successive defeats, 1-0 at Swansea City AFC in the Premier League on 22 January and 3-2 at home to West Bromwich Albion FC in the FA Cup fourth round five days later.
• Liverpool have won only two of their last five matches in all competitions, losing two; they were 2-0 winners at Southampton FC on Sunday.
• Sunday was a fifth clean sheet for Jürgen Klopp's side in their 19 away games in all competitions this season.
• Mohamed Salah has five goals in his last four games, and eight in his last seven The Egyptian has 22 Premier League goals in 26 appearances this season.
• Nathaniel Clyne has not played this season due to a back injury – although he has been added to Liverpool's UEFA Champions League squad.
• Joe Gomez (out since 30 January, knee), Ragnar Klavan (24 January, thigh) and Adam Lallana (22 January, muscle) have all been sidelined; the latter returned as a late substitute at Southampton.