There has been little between Manchester United and Valencia, with five draws in eight previous meetings.
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There has been little between Manchester United and Valencia in their eight previous meetings, although the English side hold an early advantage over their Spanish rivals in Group H.
• On matchday one, United eased to a 3-0 victory at newcomers Young Boys – Paul Pogba scoring twice – while Valencia were unable to capitalise on the first-half dismissal of Juventus forward Cristiano Ronaldo, conceding two penalties to lose 2-0 at Mestalla.
• Five of the clubs' previous eight fixtures – and four of the last five – have ended in draws, most recently in the 2010/11 group stage when they shared a 1-1 draw at Old Trafford. United had won 1-0 in Spain with a late Javier Hernández strike.
• That was United's second victory against Valencia, whose sole win against the English club came in the sides' second meeting – a 2-1 victory at Mestalla in the 1982/83 UEFA Cup first round second leg, completing an aggregate victory by the same scoreline.
• Second in last season's Premier League, United are in the group stage for the second year running and the 22nd time overall – fewer only than the 23 participations of Real Madrid, Barcelona and Porto.
• José Mourinho's side finished top of their section in 2017/18 ahead of Basel, CSKA Moskva and Benfica, but then bowed out in the first knockout round, losing 2-1 on aggregate to Sevilla (0-0 away, 1-2 home) in the last 16.
• The defeat by Sevilla means United have now won two of their last 13 matches against Spanish clubs, with five draws and six defeats in that time.
• The Red Devils have lost only three of their last 21 European matches, home and away (W14 D4).
• United won all three home games in last season's group stage; the Sevilla loss ended a 21-match unbeaten run in Europe at Old Trafford (W17 D4), since a 2-1 reverse against Real Madrid in the 2012/13 UEFA Champions League round of 16 second leg.
• Fourth in the Spanish Liga in 2017/18, this is Valencia's 11th UEFA Champions League group stage campaign. Finalists in both 1999/2000 and 2000/01, they have not reached the last 16 since 2012/13.
• Valencia did not take part in UEFA club competition in either of the last two seasons. In their most recent campaign, 2015/16, they finished third in their UEFA Champions League section to move into the UEFA Europa League, where they beat Rapid Wien 10-0 on aggregate in the round of 32 before losing on away goals to fellow Spanish side Athletic Club in the round of 16 (0-1 away, 2-1 home).
• Los Blanquinegros have lost their last four UEFA Champions League fixtures, and six of their last nine in the competition proper.
• Valencia have, however, won three of their last seven UEFA Champions League away matches, qualifying included (D1 L3).
• The Spanish side have won only three of their 17 away games against Premier League clubs (D9 L5), although their two most recent trips both produced 1-0 victories, against Swansea and Stoke in the UEFA Europa League.
Links and trivia
• Mourinho was in charge of Real Madrid between 2010 and 2013 and won six of his ten games against Valencia, drawing the other four.
• Juan Mata made 129 league appearances for Valencia between 2007 and 2011, scoring 33 goals.
• Andreas Pereira spent 2017/18 on loan at Valencia, scoring once in 23 Liga matches.
• Eric Bailly played under Valencia coach Marcelino while at Villarreal between 2015 and 2016, making 35 Liga appearances for the club.
• Have also played in Spain:
Ander Herrera (Zaragoza 2008–11, Athletic Club 2011–14)
Alexis Sánchez (Barcelona 2011–14)
David de Gea (Atlético Madrid 2009–11)
• Herrera was sent off twice in nine appearances against Valencia for Zaragoza and Athletic.
• Have played in England:
Gabriel (Arsenal 2015–17)
Francis Coquelin (Arsenal 2011–17)
Michy Batshuayi (Chelsea 2016–18)
Rodrigo (Bolton 2010/11)
• Have played together:
Eric Bailly & Denis Cheryshev (Villarreal, 2015)
• International team-mates:
David de Gea, Juan Mata, Ander Herrera & Rodrigo, José Gayà (Spain)
Paul Pogba, Anthony Martial & Kevin Gameiro (France)
Romelu Lukaku, Marouane Fellaini & Michy Batshuayi (Belgium)
Fred, Andreas Pereira & Neto (Brazil)
Marcos Rojo, Sergio Romero & Ezequiel Garay (Argentina)
• Summer transfers
In: Fred (Shakhtar Donetsk), Diogo Dalot (Porto), Lee Grant (Stoke City)
Out: Michael Carrick (retired), Sam Johnstone (West Brom), Daley Blind (Ajax), Cameron Borthwick-Jackson (Scunthorpe, loan), Joel Pereira (Vitória FC, loan), Axel Tuanzebe (Aston Villa, loan), Timothy Fosu-Mensah (Fulham, loan)
• United opened the season with a home Premier League win against Leicester but then lost at Brighton (2-3) and at home to Tottenham (0-3) – the first time they had lost successive games in all competitions since September 2016. It was also the first time the club had conceded three goals in consecutive games since losing to Blackburn and Newcastle in December 2011/January 2012.
• Mourinho's side suffered their third Premier League defeat of the season on Saturday, going down 3-1 at West Ham. Ten points from seven games represents the club's worst start to a league campaign since 1989/90.
• The Red Devils were knocked out of the League Cup by Derby on 25 September, the Championship club winning 8-7 on penalties after a 2-2 draw at Old Trafford. Phil Jones was the only player to miss in the shoot-out.
• The 1-1 draw against Wolves on 22 September was the first match former United manager Sir Alex Ferguson had attended since having emergency brain surgery in May.
• Paul Pogba scored in the first two games of the Premier League season for the second campaign in a row.
• Romelu Lukaku had scored seven goals in six matches for club and country before matchday one, but has drawn a blank in his last four appearances.
• Marcos Rojo, who has not played this season, is suffering from a minor injury.
• Summer transfers
In: Uroš Račić (Crvena zvezda), Geoffrey Kondogbia (Inter, loan made permanent), Mouctar Diakhaby (Lyon), Daniel Wass (Celta Vigo), Cristiano Piccini (Sporting CP), Michy Batshuayi (Chelsea, loan), Kevin Gameiro (Atlético), Denis Cheryshev (Villarreal, loan), Gonçalo Guedes (Paris)
Out: João Cancelo (Juventus), Nacho Vidal (Osasuna), Nemanja Maksimović (Getafe), Zakaria Bakkali (Anderlecht), Nani (Sporting CP), Martín Montoya (Brighton), Álvaro Medrán (Rayo Vallecano, loan), Simone Zaza (Torino, loan)
• Valencia were without a win in seven matches (D5 L2) in all competitions this season before Saturday's 1-0 victory at Real Sociedad. Matchday one is the only loss in their last six outings.
• The Spanish side have eight points after seven games in the new Liga season – seven fewer than at the same stage of 2017/18.
• Kevin Gameiro opened his scoring account for Valencia at Real Sociedad, his eighth appearance for the club in all competitions.
• Michy Batshuayi scored his first Valencia goal for the club on his first Liga start in a 1-1 draw with Celta Vigo on 26 September.