Roma continued their dogged pursuit of Juventus and Wayne Rooney became Manchester United's all-time record scorer, amid wins for fellow last-32 hopefuls including Beşiktaş and Lyon.
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Roma kept pace with Juventus in the Serie A title hunt and Wayne Rooney became Manchester United's all-time record scorer on a weekend of domestic tests for the UEFA Europa League sides.
Responding to a 27th consecutive home win for Juventus in the Italian top flight on Sunday afternoon, Roma recorded a narrow 1-0 success against Cagliari in the late kick-off. Edin Džeko made the difference with his 14th league effort this term to keep the Giallorossi within a point of Juve, though they have played one game more.
Eighth-placed Fiorentina had a more comfortable run-out in their 3-0 success at Chievo, while Rooney grabbed headlines in the Premier League with his 250th goal for Manchester United – a superb late free-kick equaliser against Stoke taking him past Sir Bobby Charlton in the history books. United's fellow English hopefuls Tottenham drew 2-2 away with Manchester City.
Elsewhere, Lyon clinched an impressive 3-1 triumph at home to Marseille courtesy of an Alexandre Lacazette double, and Spain's trio of UEFA Europa League teams managed just a point between them – Athletic holding Atlético 2-2. Schalke won for the first time in six outings and APOEL slotted seven goals past AEZ Zakakiou in Cyprus.
On Monday, Ryan Babel opened his Beşiktaş account as the Black Eagles beat Alanyaspor 4-1 to go top of the Turkish Super League.
Athletic Club 2-2 Atlético Madrid
Real Sociedad 1-0 Celta Vigo
Lyon 3-1 Marseille
St-Étienne 2-1 Angers
Roma 1-0 Cagliari
Fenerbahçe 1-0 İstanbul Başakşehir
Osmanlıspor 1-2 Antalyaspor
Utrecht 0-1 Ajax
Anderlecht 3-1 Sint-Truiden
APOEL 7-0 AEZ Zakakiou
Manchester City 2-2 Tottenham Hotspur
Stoke City 1-1 Manchester United
Villarreal 0-2 Valencia
Schalke 1-0 Ingolstadt
Darmstadt 0-0 Borussia Mönchengladbach
Chievo 0-3 Fiorentina
AZ Alkmaar 1-1 Sparta Rotterdam
Olympiacos 2-0 Xanthi
Eupen 0-1 Genk
Meccabi Petach-Tikva 1-1 Hapoel Beer-Sheva
Astra Giurgiu: the Romanian Liga 1 is on winter break until the weekend of 4 February
Legia Warszawa: the Polish Ekstraklasa is on winter break until the weekend of 11 February
Ludogorets Razgrad: the Bulgarian A League is on winter break until the weekend of 11 February
Sparta Praha: the Czech First League is on winter break until the weekend of 18 February
København: the Danish Super League is on winter break until the weekend of 18 February
Shakhtar Donetsk: the Ukrainian Premier League is on winter break until the weekend of 25 February
Krasnodar, Rostov, Zenit: the Russian Premier-Liga is on winter break until the weekend of 4 March