Having won all four Group K games, Lazio are already through as section winners, while bottom side Vitesse need to win and hope for a favourable result in the other game.
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The only one of the 48 clubs in the UEFA Europa League group stage to have won all four of their opening fixtures, Lazio are already through to the round of 32 as Group K winners as they face bottom-placed Vitesse in Rome.
• While the Serie A side can become only the ninth team – and eighth club – to qualify from a UEFA Europa League group with maximum points, their Dutch opponents will be eliminated unless they win and the other match between Nice and Zulte Waregem is drawn.
• Lazio opened their campaign with a 3-2 victory in Arnhem on matchday one – the clubs' first meeting in UEFA competition. Vitesse led twice, through Tim Matavž and Bryan Linssen, but the visitors came back to take three points with goals from Marco Parolo, Ciro Immobile and Alessandro Murgia.
• Lazio's five games against Dutch opponents have brought two wins, one draw and two defeats. They have won once and lost once in Rome.
• Vitesse's record in five matches with Italian sides is W1 D2 L2 (D1 L1 in Italy).
• Lazio are undefeated in 26 UEFA Europa League group games (W16 D10) and have now qualified for the knockout phase in each of their last five participations.
• Lazio have won seven of their last eight European home fixtures, the sole exception a 3-0 defeat by Sparta Praha in the 2015/16 UEFA Europa League round of 16. They beat Nice 1-0 with an added-time own goal on matchday four.
• Vitesse have not won in ten European matches (D2 L8) and are also without a victory in their last eight UEFA away games (D4 L4) – a run stretching back over 15 years to a 1-0 victory at Rapid Bucureşti in October 2002.
• UEFA Cup runners-up in 1998 and UEFA Cup Winners' Cup winners the following year, Lazio are back in the UEFA Europa League after a one-season absence, having progressed to the last 16 in 2015/16.
• Vitesse are featuring in the group stage of a UEFA competition for the first time – reward for having won the 2016/17 Dutch Cup, their maiden major trophy.
Links and trivia
• The journey from Arnhem to Rome is around 1,200km.
• Lazio have Dutch talent in their ranks – defender Stefan de Vrij, who played for Feyenoord from 2009–14.
• Vitesse strikers Matavž (Genoa, 2016) and Luc Castaignos (Internazionale, 2011–12) have both played in Italy, but neither figured for their Serie A clubs against Lazio.
• Vitesse's Alexander Büttner is suspended after his red card against Zulte Waregem on matchday four.
• Misses next match if booked: Luis Felipe (Lazio); Thulani Serero, Thomas Bruns (Vitesse).
• Lazio boss since 2016, Simone Inzaghi represented the club as a forward from 1999–2010, and stayed on to coach the youth teams. He is the younger brother of fellow ex-Italian international Filippo Inzaghi, the pair having initially played together at home-town outfit Piacenza.
• Vitesse coach since 2016, leading them to their historic Dutch Cup triumph last season, Surinam-born Henk Fraser was capped seven times by the Netherlands as a defender, spending the bulk of his playing career at Feyenoord, where he was later a youth coach. He took his first senior job at Den Haag from 2014–16.