Borussia Dortmund, Molde, Napoli and Rapid Wien are through to the round of 32 with two games to spare, while Skënderbeu gained their first group stage win at Sporting CP's expense.
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Borussia Dortmund and Napoli turned on the style on UEFA Europa League matchday four, prevailing 4-0 and 5-0 respectively, as they booked their places in the round of 32 alongside fellow winners Molde and Rapid Wien.
Napoli took their goal tally in Group D to 16 by overwhelming Midtjylland. Rapid, 2-1 victors at Viktoria Plzeň, and the Serie A club are the only sides with 100% records. Braga, however, dropped their first points, losing 1-0 to Marseille.
Molde's progress from Group A means two from Ajax, Celtic and Fenerbahçe will miss out on qualification for the knockout stage. Daniel Hestad, aged 40 years and 98 days, became the competition's oldest scorer when he put the Norwegian outfit 2-1 up at Celtic Park.
Marco Reus, Pierre-Emerick Aubameyang and Henrikh Mkhitaryan struck as Dortmund defeated Qäbälä 4-0. Elsewhere, former Schwarzgelben coach Jurgen Klöpp guided Liverpool to their first European win of the season – the Reds ending a run of three draws with a 1-0 success at Rubin Kazan – while Skënderbeu recorded Albania's first group stage triumph at ten-man Sporting CP's expense.