Roma and Fenerbahçe both lost this weekend and Anderlecht missed an opening in Belgium, while fellow last-32 sides Manchester United and Tottenham progressed in the FA Cup.
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There were regrets aplenty among the UEFA Europa League contenders at the weekend as Roma and Fenerbahçe lost ground in their domestic title hunts and Anderlecht spurned the chance to go top in Belgium.
Roma's pursuit of Juventus took a hit as the Giallorossi suffered a surprise 3-2 loss at Sampdoria after taking an early lead through Bruno Peres. The result left the capital side four points adrift of Juve having played one game more, while there were goals too as fellow last-32 hopefuls Fiorentina drew 3-3 at home with Genoa.
As for Fenerbahçe, they slipped to their first defeat in ten games in all competitions in a 4-1 reverse at Kayserispor. Their heaviest Süper Lig loss since they went down 3-0 at Beşiktaş in November 2009, that left Fener seven points shy of leaders İstanbul Başakşehir in fourth.
Anderlecht are a point off the Belgian summit, meanwhile, having been unable to build on a 2-0 victory for UEFA Europa League compatriots Gent at home to pacesetters Club Brugge. Instead, they could only draw 0-0 with nine-man Standard Liège. There was better news for the English contingent, as both Manchester United and Tottenham progressed through to the FA Cup fifth round.
Gençlerbirliği 1-1 Osmanlıspor
Gent 2-0 Club Brugge
Vitesse 2-1 AZ
Ajax 3-0 Den Haag
Ethnikos Achnas 2-3 APOEL
Fiorentina 3-3 Genoa
Sampdoria 3-2 Roma
Panetolikos 0-1 PAOK
Manchester United 4-0 Wigan (FA Cup last 32)
Kayserispor 4-1 Fenerbahçe
Toulouse 0-3 St-Étienne
Anderlecht 0-0 Standard
Veria 1-2 Olympiacos
Athletic 2-1 Sporting Gijón
Astra Giurgiu: the Romanian Liga 1 is on winter break until the weekend of 4 February
København: the Danish Super League is on winter break until the weekend of 18 February
Krasnodar, Rostov, Zenit: the Russian Premier-Liga is on winter break until the weekend of 4 March
Legia Warszawa: the Polish Ekstraklasa is on winter break until the weekend of 11 February
Ludogorets Razgrad: the Bulgarian A League is on winter break until the weekend of 11 February
Shakhtar Donetsk: the Ukrainian Premier League is on winter break until the weekend of 25 February
Sparta Praha: the Czech First League is on winter break until the weekend of 18 February