Manchester United, Krasnodar and Schalke are the first teams through to the round of 16 after completing fairly comfortable wins on Wednesday, with Fenerbahçe bowing out.
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Fenerbahçe 1-1 Krasnodar (agg: 1-2)
Fedor Smolov scored from the visitors' first attack as the Russian side reached the round of 16 for the first time. Souza gave the hosts hope before half-time, but the away goals rule meant the Turkish team still needed two more and they never really looked like getting them.
St-Étienne 0-1 Manchester United (agg: 0-4)
Henrikh Mkhitaryan struck early before limping off as United eased into the last 16 with a comfortable win. Eric Bailly was sent off in the second half.
Schalke 1-1 PAOK (agg: 4-1)
Leading 3-0 from last week, Schalke all but sealed it with Alessandro Schöpf's well-worked opener. Matija Nastasić's own goal swiftly brought PAOK level, though it was Schalke who came closest to victory on the night, Thilo Kehrer's late deflected effort rattling the crossbar.