PSV Eindhoven were the big-name fallers but fellow former European champions Crvena zvezda, Marseille and Milan made safe progress to the UEFA Europa League play-offs.
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AEL Limassol 1-2 Austria Wien (agg: 1-2)*
Altach 3-1 Gent (agg: 4-2)
Apollon Limassol 2-0 Aberdeen (agg: 3-2)
Athletic Club 3-0 Dinamo București (agg: 4-1)
Braga 2-1 AIK (agg: 3-2, after extra time)
Dinamo Minsk 1-1 AEK Larnaca (agg: 1-3)
Domžale 2-0 Freiburg (agg: 2-1)
Fenerbahçe 1-1 Sturm Graz (agg: 3-2)
Fola Esch 1-2 Östersund (agg: 1-3)
Gabala 1-2 Panathinaikos (agg: 1-3)
Hajduk Split 2-0 Brøndby (agg: 2-0)
Lech Poznań 2-2 Utrecht (agg: 2-2, Utrecht win on away goals)
Lyngby 1-3 Krasnodar (agg: 2-5)
Marítimo 2-0 Botev Plovdiv (agg: 2-0)
Milan 2-0 CSU Craiova (agg: 3-0)
Midtjylland 2-1 Arka Gdynia (agg: 4-4, Midtjylland win on away goals)
Odd 0-0 Dinamo Zagreb (agg: 1-2)
Olexandriya 1-0 Astra Giurgiu (agg: 1-0)
Oostende 0-0 Marseille (agg: 2-4)
Osijek 1-0 PSV Eindhoven (agg: 2-0)
Panionios 0-1 Maccabi Tel-Aviv (agg: 0-2)
PAOK 2-0 Olimpik Donetsk (agg: 3-1)
Ružomberok 0-1 Everton (agg: 0-2)
Shkëndija 3-0 Trakai (agg: 4-2)
Sion 1-1 Sūduva (agg: 1-4)*
Skënderbeu 2-1 Mladá Boleslav (agg: 3-3, Skënderbeu win 4-2 on penalties)
Sparta Praha 0-1 Crvena zvezda (agg: 0-3)
Videoton 1-0 Bordeaux (agg: 2-2, Videoton win on away goals)
Zenit 0-1 Bnei Yehuda Tel-Aviv (agg: 2-1)
*Second legs were played Wednesday
Osijek claimed the biggest scalp of the round in PSV Eindhoven, but the three other European champions involved – Crvena zvezda, Marseille and Milan (the Rossoneri in front of a UEFA Europa League qualifying/play-off record 65,763 crowd at San Siro) – all progressed to the play-offs.
Petar Bočkaj's first-half free-kick extended the Croatian side's aggregate advantage as PSV were eliminated. The other continental title holders marched on however, as did Athletic Club, Everton and Fenerbahçe, but Bundesliga representatives Freiburg were knocked out by Slovenian team Domžale.
Zenit, who lifted this trophy in 2007/08, survived to live another round despite a home defeat by Bnei Yehuda. No such luck for 1996 UEFA Cup runners-up Bordeaux, though, who lost on away goals to their 1985 counterparts Videoton of Hungary.
Swedish debutants Östersund, Galatasaray's second qualifying round conquerors, also advanced. Fellow Allsvenskan club AIK succumbed to a 121st-minute goal at Braga, the 2011 finalists.
The UEFA Europa League play-off draw – which contains 29 teams that have come from the third qualifying round as well as 15 transferring from UEFA Champions League qualification – will be streamed live on UEFA.com from 13:00CET on Friday. The full draw procedure is explained here. Ties will be played on 17 and 24 August.