Lyon, Wolfsburg, Bayern München and Paris Saint-Germain hold comfortable leads but it is closer for the likes of Manchester City and Barcelona as the round of 16 ends.
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- Five round of 16 second legs on Wednesday; remaining three on Thursday
- Draw for quarter-finals and beyond streamed live from Nyon on 25 November
- Road to Cardiff: calendar
Wednesday's second legs:
Brøndby (0-1) Manchester City
Debutants City only managed a narrow home win against the three-time semi-finalists from Denmark but in the round of 32 the English champions won just 2-0 against Zvezda-2005 in Manchester but triumphed 4-0 in Russia.
Zürich (0-8) Lyon
Holders Lyon now have 29 goals in four European games at their new stadium and after Sunday's 5-0 league win at Rodez have scored 65 times in their ten fixtures this season. Lyon's last competitive away defeat (other than on penalties) was in March 2010, a 1-0 loss at Italy's Torres in a UEFA Women's Champions League quarter-final OL already led 3-0.
Rosengård (3-1) Slavia Praha
In the only meeting between two of last season's quarter-finalists, a fine first leg in Prague was capped for the Swedish side by the penalty converted by Gaëlle Enganamouit in her first European match since an injury for her new club in April.
Twente (0-1) Barcelona
Barcelona won 1-0 home and away at this stage against Twente last season and kept up that sequence in the first leg. Last year's meeting at FC Twente Stadion, venue for August's UEFA Women's EURO 2017 final, was the opening leg of that tie and attracted a round of 16 record crowd of 15,637.
Fortuna Hjørring (1-0) Brescia
Since the current competition system was introduced in 2009/10, each season Fortuna have got through the round of 32 only to lose in the last 16. The 2003 runners-up look set to break that hoodoo after their victory in Brescia, where they lost 1-0 in the first leg 12 months ago before a 1-1 home draw.
Thursday's second legs:
Paris Saint-Germain (3-0) BIIK-Kazygurt
BIIK are the first side from Kazakhstan to make it this far but seem to be coming to the end of the road as they visit 2015 finalists Paris, who are yet to concede in seven league games this season.
Rossiyanka (0-4) Bayern München
Whereas all other German entrants – FFC Frankfurt, Turbine Potsdam, Duisburg and Wolfsburg – won the European title on debut, Bayern have never got further than the round of 16 in their two previous bids. That looks set to change as they take a four-goal lead to the Russian champions, Bayern having also beaten Frankfurt 1-0 on Sunday to move up to second in Germany.
Wolfsburg (5-1) Eskilstuna United
Last season's runners-up and two-time champions Wolfsburg are on course to make it a German double in the quarter-finals after their comfortable win in Sweden, where Zsanett Jakabfi scored four goals to add to her round of 32 hat-trick away to Chelsea. Anja Mittag was again on as a substitute and remains stuck on 49 UEFA women's club competition goals, one off the first half-century.