Debutants Manchester City, holders Lyon, Barcelona, Rosengård and Fortuna Hjørring all booked their places in March's quarter-finals as five second legs were completed.
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- Debutants Manchester City and holders Lyon among five teams to book quarter-final slots
- Rosengård, Barcelona and Fortuna also make it through
- Remaining three second legs on Thursday
- Draw for quarter-finals and beyond streamed live from Nyon on 25 November
- Road to Cardiff: calendar
Brøndby 1-1 Manchester City (agg: 1-2)
Manchester City will take their debut campaign into the quarter-finals as they made full use of their 1-0 home win. After a tight first half, City picked up the pace and on 65 minutes Toni Duggan got their away goal with a superb shot on the turn. Nanna Christiansen immediately equalised on the night but the three-time semi-finalists remained two goals short.
Zürich 0-9 Lyon (agg: 0-17)
The holders went one better than their first-leg win and now have 74 goals in 11 competitive matches this season. Camille Abily scored twice before half-time and substitute Claire Lavogez matched her in the 62nd and 63rd minutes, her strikes following within seconds by another from Mylaine Tarrieu. Dzsenifer Marozsán was at the heart of Lyon's play, notably for her superb dribble to set up Abily for the third.
Rosengård 3-0 Slavia Praha (agg: 6-1)
It is a fifth quarter-final in six seasons for Rosengård after three goals in the first 19 minutes completed the job against another side that reached the last eight a year ago. Early on Ella Masar was set up by Gaëlle Enganamouit before the Cameroon forward, who only returned in recent weeks from long-term injury, added two more herself in the space of 60 seconds, the first a thunderbolt shot from 15 metres followed by an individual effort as she rounded the goalkeeper and tapped in.
Twente 0-4 Barcelona (agg: 0-5)
Despite the support of more than 7,000 fans at the stadium that will host the UEFA Women's EURO 2017 final, Twente bowed out for the second year running to Barcelona at this stage. It had been 1-0 to Barcelona in the previous three meetings but their dominance was more pronounced from the start tonight as Marta Torrejón and Andressa Alves scored before half-time and substitutes Bárbara Latorre and Ange Nguessan finished off counterattacks following the interval.
Fortuna Hjørring 3-1 Brescia (agg: 4-1)
Having lost in the round of 16 every season since it was introduced in 2009/10, the 2003 runners-up Fortuna are into the quarter-finals at last, avenging their elimination 12 months ago by Brescia. Maria Christensen made two fine saves and several more crucial clearances to keep the visitors out before the outstanding Florentina Olar doubled the Danish side's aggregate advantage in the 36th minute. Two second-half goals by Camilla Kur Larsen, the second from distance, put the tie beyond Brescia despite Raffaella Manieri pulling one back.
Reporters: Stefan Lecca, Ulf Nilsson, Martijn Sterke & Rasmus Munch