A star substitute scored three for Tottenham while Roma and Feyenoord picked up three points on Matchday 2.
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Harry Kane came off the bench to score the first hat-trick in UEFA Europa Conference League history, his 20-minute treble crowning a 5-1 win against Slovenia's Mura.
Roma had a comfortable evening too, a 3-0 win at Zorya Luhansk making them the group stage's top scorers so far with eight goals, while Feyenoord were made to work hard for their three points against Slavia Praha.
UEFA.com rounds up the Thursday night action.
José Mourinho's side had a comfortable night in Ukraine, two goals in the space of three minutes from Englishmen Chris Smalling and Tammy Abraham setting the seal on victory. Stephan El Shaarawy had them in front inside ten minutes, but it took until the second half for Smalling's tap-in and Abraham's effort to end the contest.
José Mourinho, Roma coach: "The result is what I liked the most tonight, and the result is what matters most. We won, and it's important to be on six points, one step closer to qualification. We were able to rest some players and we didn't pick up injuries: all positive. It's always important to win, and we want to transfer this to the league."
The hosts blew the Czech champions away in the first half, Orkun Kökçü finding the target with a low, left-footed shot before Tyrell Malacia set up Bryan Linssen to head in at the far post. However, Slavia had a rethink at the break and gave their hosts a scare, Tomáš Holeš meeting a free-kick with a fine header to haul them back into the game.
Key stat: Feyenoord have won all four of their home games in UEFA competition this season, scoring 13 goals in the process. As former European Cup and UEFA Cup winners, they could complete a unique club competition treble by winning this trophy.
On as a 59th-minute substitute, Harry Kane registered in the 68th, 76th and 87th minutes as Mura came unstuck at Tottenham. Dele Alli and Giovani Lo Celso struck in the first ten minutes before a rocket from Žiga Kous raised the spectre of a shock comeback. However, Kane confirmed the three points for Nuno Espírito Santo's side.
Key stat: Kane is the first player to have scored a hat-trick in the UEFA Champions League, UEFA Europa League and UEFA Europa Conference League.
Best of the rest
- Brothers Riku and Roope Riski both scored as HJK Helsinki won 4-2 away against Armenian champions Alashkert, Roope providing the assist for his older sibling's finish.
- The only newcomers to win on Matchday 1, Bodø/Glimt remain unbeaten after a 0-0 draw at CSKA-Sofia. They welcome Roma on Matchday 3.
- Copenhagen's Jonas Wind is level with Kane at the top of the UEFA Europa Conference League goalscorers ranking after taking his personal tally to three for the season with a penalty against Lincoln Red Imps.
All the Matchday 2 results
Group A: Alashkert 2-4 HJK, LASK 1-1 M. Tel-Aviv
Group B: Partizan 2-0 Flora, Gent 2-0 Anorthosis
Group C: CSKA-Sofia 0-0 Bodø/Glimt, Zorya Luhansk 0-3 Roma
Group D: CFR Cluj 1-1 Randers, AZ Alkmaar 1-0 Jablonec
Group E: Union Berlin 3-0 M. Haifa, Feyenoord 2-1 Slavia Praha
Group F: PAOK 1-1 Slovan Bratislava, Copenhagen 3-1 Lincoln Red Imps
Group G: Vitesse 1-2 Rennes, Tottenham 5-1 Mura
Group H: Omonoia 1-4 Qarabağ, Basel 4-2 Kairat