The competition will conclude in Nyon next month with Real Madrid CF playing SL Benfica and FC Schalke 04 facing FC Barcelona, followed by the final three days later.
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Two teams from Spain and one apiece from Germany and Portugal will contest the UEFA Youth League semi-finals in Nyon, Switzerland, next month.
Domestic rivals FC Barcelona and Real Madrid CF will play in opposite last-four ties to one another, raising the possibility of an all-Spanish showpiece when the inaugural competition reaches its climax over three days at the Colovray Stadium in mid-April.
Like the single-leg knockout games before them, the semi-finals – which will also feature FC Schalke 04 and SL Benfica – and final will be decided by penalty kicks should a match be level after 90 minutes. The overall winners will receive the Lennart Johansson Trophy, UEFA's newest piece of silverware, which is named after the governing body's Swedish honorary president.
Semi-finals (11 April, Nyon)
Real Madrid CF v SL Benfica (13.00CET)
FC Schalke 04 v FC Barcelona (16.30CET)
Final (14 April, Nyon)
Winner of semi-final 1 v Winner of semi-final 2 (16.30CET)