The domestic champions path winners will meet the runners-up from the UEFA Champions League path group stage on 8/9 February.
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The UEFA Youth League play-offs are on 8 and 9 February, with the winners joining the teams that finished top of the UEFA Champions League path groups in the round of 16.
In the play-offs, the winners of the eight domestic champions path second-round ties have been drawn at home to the runners-up from the UEFA Champions League path group stage.
Tuesday 8 February
Wednesday 9 February
• Midtjylland are in this round for the fifth time in the six seasons since the current format was introduced, all via the domestic champions path. All four of their previous ties went to penalties, the Danish side winning three times.
• Atlético are also in this round for the fifth time, having never failed to get past the group stage in any of this competition's eight editions. They have won three play-offs, losing only to Midtjylland on penalties in 2014/15 after a 4-4 draw.
• AZ, Deportivo, Empoli and Hajduk are through on debut while Genk, Villarreal and Žilina have made it to the play-offs for the first time. Rangers and Žilina hope to be the first teams from their nations to reach the round of 16.
• Club Brugge are also aiming to get to the round of 16 for the first time.
• Two-time champions Chelsea reached the 2019 final from the play-offs (having entered in the domestic champions path).
Knockout draw (round of 16 onwards): 14 February, Nyon
Round of 16: 1/2 March
Quarter-finals: 15/16 March
Semi-finals: 22 April, Nyon
Final: 25 April, Nyon
Through to round of 16 (group winners): knockout draw 14 February
Benfica, Juventus, Liverpool, Manchester United, Paris Saint-Germain, Real Madrid (holders), Salzburg, Sporting CP