The draw took place at UEFA headquarters in Nyon on 28 February.
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İstanbul Başakşehir (TUR) vs Copenhagen (DEN)
Olympiacos (GRE) vs Wolves (ENG)
Rangers (SCO) vs Leverkusen (GER)
Wolfsburg (GER) vs Shakhtar Donetsk (UKR)
Internazionale Milano (ITA) vs Getafe (ESP)
Sevilla (ESP) vs Roma (ITA)
Eintracht Frankfurt (GER) / Salzburg (AUT)* vs Basel (SUI)
LASK (AUT) vs Manchester United (ENG)
* Second leg on Friday at 18:00 CET
- There was no seeding or country protection.
- The 16 balls were placed in a large central bowl and shuffled. The first team drawn earned a first leg at home against the second team drawn. The same procedure was then be repeated for the other ties.
12 March: first leg
19 March: second leg