Sevilla FC coach Juande Ramos insists his players must "channel all their energy" into their encounter with Jean Tigana's Beşiktaş JK.
The game in Spain is Sevilla's first in the section, and Ramos is wary of the threat posed by Beşiktaş. "We are facing the group favourites and one of the top seeds in the draw. They have a new coach [Jean Tigana] and we don't know if he has changed their style of play. We do know that they are a difficult side, one that has several big-name players, so we expect a tight contest."
Ramos is without winger Jesús Navas (sprained ankle) and centre-back Ivica Dragutinović (thigh tear) while striker Ariza Makukula is a long-term absentee (knee). Daniel and Aitor Ocio have recovered from knocks and are available after watching their team draw 1-1 at RCD Mallorca on Sunday.
Appointed on Monday, Tigana will lead Beşiktaş for the first time. Although he has just taken charge, the Frenchman already has a number of injury problems as his team seek to add to the point achieved at home to Bolton Wanderers FC on Matchday 1.
Midfielder Sergen Yalçın is out with a torn hamstring. Having scored an early free-kick in Sunday's 4-2 home win against MKE Ankaragücü, he had to be substituted after injuring himself in the celebrations. Kleberson, Tayfur Havutçu and Gökhan Zan are also sidelined.
Turkish international Okan Buruk said: "Sevilla play very well at home, but we want to get points there." Meanwhile, defender Ali Güneş was positive about Tigana's arrival, saying: "A new coach always means fresh motivation. We want a good result in the first match of his reign."