Will Fenerbahçe hit the buffers? How do you stop Aritz Aduriz and Sparta? Have Napoli got what it takes to break down Villarreal? Can Rapid Wien save face?
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Homecoming for Marseille's Míchel
Thursday's trip to Bilbao will be a homecoming of sorts for Marseille's Spanish coach Míchel, who replaced former Athletic boss Marcelo Bielsa in the OM dugout last August. He will refuse to be distracted, though, as his team need to overturn a 1-0 round of 32 first-leg deficit. "I'd have prefered to be back in Spain in a better situation," he said, describing Athletic as a "tough team who have gifted forwards in Aritz Aduriz and Raúl García".
Athletic v Marseille, 19.00
Kalinić coming good?
There was good news for Fiorentina at the weekend as Nikola Kalinić ended a two-month goal drought after coming off the bench in a 3-2 victory at Atalanta. "Forwards can lose confidence when they don't score for a few games so this goal was important for him and the whole side," said coach Paulo Sousa. With the Viola required to score at Tottenham – after the 1-1 first-leg draw in Florence – the Croatian's return to form is well timed.
Tottenham v Fiorentina, 21.05
Lokomotiv expect better
"Our opponents will have a tough time in Moscow," promised Lokomotiv coach Igor Cherevchenko, although the manner of their 2-0 loss at Fenerbahce will not trouble their Turkish guests. Petar Škuletić failed to sparkle as he seeks to fill the gap left by departed attacker Baye Oumar Niasse. The Railwaymen do recall defender Vedran Ćorluka after he completed a four-match ban, yet key midfielder Dmitri Tarasov is suspended.
Lokomotiv v Fenerbahçe, 17.00
Will Villarreal's defensive prevail again?
Villarreal spoiled Napoli's 100% record in this season's UEFA Europa League with a 1-0 win last week, and they head to Italy having kept clean sheets in their last five matches. That impressive sequence includes Sunday's 0-0 draw at Atlético Madrid – the only team in the Liga with better defensive statistics – and they will target a sixth straight shut-out at the Stadio San Paolo. "This team keeps getting better with every month and every year," said boss Marcelino after the Atlético game.
Napoli v Villarreal, 21.05
Shakhtar out to shake up Schalke
UEFA Cup final winners in 2009, Shakhtar had an underwhelming first leg against Schalke, a 0-0 draw leaving them with plenty to do in Germany. However, still without Dentinho and Bernard – currently training alone – Shakhtar have an additional concern over Eduardo, who is nursing an injured knee. Serhiy Kryvtsov, meanwhile, is the most likely replacement for suspended centre-back Olexandr Kucher.
Schalke v Shakhtar, 19.00
Kononov keeping the faith
Krasnodar received further warning about the task ahead when round of 32 rivals Sparta beat Mladá Boleslav 2-0 on Sunday, the Czech side's seventh consecutive win in all competitions – achieved despite the absence of the league's joint-top scorer and captain David Lafata. Trailing 1-0 in the tie, Krasnodar must improve as an attacking force after managing just one attempt on target in Prague.
Krasnodar v Sparta Praha, 19.00
Rapid playing for pride
How do you recover from a 6-0 defeat? Rapid's players experienced a miserable night in Valencia last week, and their walk of shame did not end when they left the pitch, with fans and pundits back in Austria hardly sparing in their criticism of Zoran Barisic's side. "If you can't deal with those kinds of defeat then don't play sports," he said. "This match has left a wound but over time it will become a scar." The healing process begins in Vienna.
Rapid v Valencia, 19.00
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