Six play-off slots have been settled and two are still up for grabs in the remaining second legs on 7 and 8 December.
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The UEFA Youth League domestic champions path second round is in progress with six of the eight play-off spots on offer so far decided.
The 32 clubs involved in the UEFA Champions League path are those that take part in this season's group stage of the senior competition. They are joined in the tournament by the 32 domestic youth champions from the highest-ranked entering associations whose senior side had not qualified for the UEFA Champions League group stage – and these teams participate in the domestic champions path.
The 16 first-round ties were played in September and October. The second round runs until 8 December.
The eight second-round winners in the domestic champions path progress to February's play-offs where they will face the runners-up of the eight UEFA Champions League path groups. The winners of those ties, drawn on 14 December, then advance to the round of 16 alongside the UEFA Champions League path group winners.
Through to play-offs so far
AZ Alkmaar, Empoli, Genk, Hajduk Split, Midtjylland, Žilina
Second round ties
• Midtjylland have successfully navigated the domestic champions path on all their record five entries in the six seasons since its introduction.
• AZ, Empoli and Hajduk are through on debut while Genk and Žilina have made it to the play-offs for the first time.
• 12,189 fans watched Deportivo play Maccabi Haifa, the most ever in the domestic champions path and the fifth-highest crowd in UEFA Youth League history.
Wednesday 8 December
Maccabi Haifa vs Deportivo La Coruña (first leg: 1-5)
Tuesday 7 December
Rangers vs Septemvri Sofia (first leg: 4-2)
Wednesday 24 November
Septemvri Sofia 2-4 Rangers
Tuesday 2 November
Trabzonspor 2-5 Midtjylland
No more away goals rule
There has been a rule change for 2021/22: Ties level after the second leg go to a penalty shoot-out if required, irrespective of the number of away goals a team has scored. As before, extra time is not played in any UEFA Youth League tie.
First round results
• The crowd of 8,522 at the first-round second leg between Deportivo La Coruña and Pogoń Szczecin was the highest ever in the domestic champions path, until they topped it in the second round. Depor trailed 3-0 from the first leg but won the return 4-0 in added time.
• Competition newcomers AZ, Angers, Deportivo, Empoli, Hajduk and Trabzonspor were among the first-round winners, as were two-time quarter-finalists Midtjylland.
• Žalgiris were the first UEFA Youth League entrants from Lithuania, and Akademia e Futbollit, Csikszereda, Daugavpils, Köln, Pogoń Szczecin, Saint Patrick's Athletic and Zvijezda 09 also made debuts in the opening round.
Wednesday 20 October
Trabzonspor 2-0 Zvijezda 09 (agg: 3-0)
Kairat Almaty 1-0 APOEL (agg: 2-1)
FC Minsk 2-0 Daugavpils (agg: 6-0)
Sparta Praha 3-3 MTK Budapest (agg: 4-6)
Angers 3-0 Csikszereda (agg: 5-0)
Žilina 2-0 PAOK (agg: 7-1)
Hajduk Split 3-1 Shkëndija (agg: 5-1)
Crvena zvezda 2-0 Saint Patrick's Athletic (agg: 4-1)
Maccabi Haifa 2-0 Žalgiris Vilnius (agg: 5-0)
Hammarby 1-2 Rangers (agg: 1-5)
Empoli 1-1 Domžale (agg: 3-2)
Deportivo La Coruña 4-0 Pogoń Szczecin (agg: 4-3)
Wednesday 29 September
Daugavpils 0-4 FC Minsk
Gabala 0-4 AZ Alkmaar
Zvijezda 09 0-1 Trabzonspor
APOEL 1-1 Kairat Almaty
Septemvri Sofia 3-0 Akademia e Futibollit
MTK Budapest 3-1 Sparta Praha
Csikszereda 0-2 Angers
Köln 2-4 Genk
PAOK 1-5 Žilina
Pogoń Szczecin 3-0 Deportivo La Coruña
Domžale 1-2 Empoli
St. Patrick's Athletic 1-2 Crvena zvezda
Play-off draw: 14 December, Nyon
Play-offs: 8/9 February
Knockout draw (round of 16 onwards): 14 February, Nyon
Round of 16: 1/2 March
Quarter-finals: 15/16 March
Semi-finals: 22 April, Nyon
Final: 25 April, Nyon