Holders FFC Frankfurt needed penalties to get past LSK Kvinner on a night when Wolfsburg, Lyon, Paris Saint-Germain, Barcelona and Brescia claimed quarter-final berths.
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• Holders Frankfurt need penalties to reach quarter-finals after visitors LSK wipe out deficit
• Wolfsburg, Lyon, Paris Saint-Germain, Barcelona and Brescia also through
• Remaining two round of 16 ties conclude on Thursday
• Draw for the rest of the competition made on 27 November
FFC Frankfurt 0-2aet LSK Kvinner (agg: 2-2, 5-4pens)
Norwegian champions LSK wiped out their aggregate deficit in Germany only to fall to the holders in only the sixth penalty shoot-out in UEFA women's club competition. Clear-cut chances rare on both sides in the opening stages, but then Marit Sandvei's 12th-minute corner was headed home from close range by Emma Lundh for LSK.
Simone Laudehr hit the bar with a thunderous volley from 20 metres which could have been a well-deserved equaliser midway through the first half. After Kathrin-Julia Hendrich had brought down Lundh inside the area, Sherida Spitse could have equalised the tie from the spot, but Anne-Kathrine Kremer saved.
After the break Frankfurt sat deep and looked comfortable until Marita Lund powerfully put the ball into the net from just outside the box with 20 minutes to go after the Frankfurt defence failed to clear. Frankfurt had the better of extra time, but penalties were needed and Spitse again was key, missing LSK's fifth effort before 2015 final hero Mandy Islacker converted the winner.
Wolfsburg 2-0 Chelsea (agg: 4-1)
For the first time England will have no quarter-finalists after two-time winners Wolfsburg comfortably build on the lead they took in London. That was increased 12 minutes in by Venesaa Bernauer's brilliant looping finish from distance that gave Hedvig Lindahl no chance. The visiting European debutants continued to press, and Eniola Aluko hit the bar, but with 22 minutes to go Alex Popp pounced on a rebound and her shot was turned into her own net by Claire Rafferty. Like LSK, Chelsea will be back next year as league champions.
Paris Saint-Germain 0-0 KIF Örebro (agg: 1-1, Paris win on away goals)
Paris made the most of Anja Mittag's away goal last week in Sweden as they dominated a resilient and well-organised Örebro side, with the visitors happy to sit deep and launch counterattacks. The 66th-minute introduction of Marie-Laure Delie for last season's runners-up helped spark Paris, as she hit the post within seconds. Paris continued to attack but could not beat an inspired Carola Söberg.
Fortuna Hjørring 1-1 Brescia (agg: 1-2)
Brescia remain on course to provide a home finalist in Italy next May thanks to teenage substitute Lisa Boattin's 89th-minute goal that eliminated the 2003 runners-up. Fortuna, who have gone out in the round of 16 every season since this round was introduced in 2009/10, had levelled the tie on aggregate through Nadia Nadim on 58 minutes, and the forward went close again, but Boattin pounced in a goalmouth scramble to ensure Brescia did not need extra time in Denmark.
Barcelona 1-0 Twente (agg: 2-0)
A week on from her goal giving Barcelona victory at Twente, Olga García was on target again to send her side into their second quarter-final in three years. García finished from near the penalty spot, shooting into the roof of the net to ultimately decide an intense match. Barcelona's Melanie Serrano hit the woodwork from distance, as did Stephanie van der Gragt for Twetne, who welcomed back captain Anouk Dekker.
Lyon 6-0 Atlético Madrid (agg: 9-1)
After two consecutive round of 16 exits, twice-winners Lyon strolled through to ensure Atlético followed fellow debutants Chelsea and Örebro out of the competition. Atlético had overturned a two-goal deficit in Russia against Zorkiy in the round of 32 but there was no danger of a repeat as Lotta Schelin and Ada Hegerberg both scored twice, Saki Kumagai converted a penalty and Edolie Thomis made it six. Hegerbeg has now got two goals in all four of Lyon's European games this season.
Reporters: Steffen Potter, Mario Jurkschat, Aurélien Sagnier, Nicklas Vinde, Nicolai Lisberg & Sébastien Blanchard
Road to the final
Quarter-final & Semi-final draw: 27 November
Quarter-finals: 23/24 & 30/31 March
Semi-finals: 23/24 & 30 April/1 May
Final (Reggio Emilia): 26 May