The draw will split the contenders into four groups of four for the first 16-team finals.
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The Netherlands will host the expanded 16-team finals from 19 January to 6 February 2022 and the draw will split the hosts and 15 qualifiers into four groups of four. Matches will be played at the Amsterdam Arena, which seats 12,000, and Groningen Arena.
Quarter-final 1: Winner Group B v Runner-up Group A
Quarter-final 2: Winner Group A v Runner-up Group B
Quarter-final 3: Winner Group C v Runner-up Group D
Quarter-final 4: Winner Group D v Runner-up Group C
Semi-final 1: Winner quarter-final 2 v Winner quarter-final 4
Semi-final 2: Winner quarter-final 1 v Winner quarter-final 3
Third-place match: Loser semi-final 1 v Loser semi-final 2
Final: Winner semi-final 1 v Winner semi-final 2