Matches
12 September 2021
AEK Larnaca
2-1
-
Omonoia
20 September 2021
Omonoia
2-1
-
Doxa
26 September 2021
Omonoia
1-1
-
Pafos
03 October 2021
Olympiakos
1-0
-
Omonoia
17 October 2021
Omonoia
1-0
-
Apollon
25 October 2021
P.A.E.E.K.
1-0
-
Omonoia
29 October 2021
Omonoia
0-1
-
Anorthosis
07 November 2021
Ethnikos Achnas
0-2
-
Omonoia
21 November 2021
Omonoia
3-0
-
Aris Limassol
29 November 2021
APOEL
0-0
-
Omonoia
Match suspended
05 December 2021
AEL
-
-
Omonoia
13 December 2021
Omonoia
-
-
AEK Larnaca
19 December 2021
Doxa
-
-
Omonoia
22 December 2021
Omonoia
-
-
AEL
03 January 2022
Pafos
-
-
Omonoia
08 January 2022
Omonoia
-
-
Olympiakos
15 January 2022
Apollon
-
-
Omonoia
22 January 2022
Omonoia
-
-
P.A.E.E.K.
29 January 2022
Anorthosis
-
-
Omonoia
05 February 2022
Omonoia
-
-
Ethnikos Achnas
12 February 2022
Aris Limassol
-
-
Omonoia
19 February 2022
Omonoia
-
-
APOEL