Matches
21 August 2021
Pafos
4-0
-
APOEL
13 September 2021
APOEL
0-1
-
Olympiakos
19 September 2021
Apollon
2-1
-
APOEL
27 September 2021
APOEL
1-0
-
P.A.E.E.K.
03 October 2021
Anorthosis
2-1
-
APOEL
18 October 2021
APOEL
2-1
-
Ethnikos Achnas
24 October 2021
Aris Limassol
0-1
-
APOEL
30 October 2021
Doxa
2-2
-
APOEL
06 November 2021
APOEL
3-0
-
AEL
22 November 2021
AEK Larnaca
0-0
-
APOEL
05 December 2021
APOEL
1-1
-
Pafos
12 December 2021
Olympiakos
1-1
-
APOEL
18 December 2021
APOEL
1-1
-
Apollon
26 December 2021
APOEL
4-2
-
Omonoia
15 January 2022
Ethnikos Achnas
0-3
-
APOEL
23 January 2022
APOEL
1-1
-
Aris Limassol
30 January 2022
APOEL
-
-
Doxa
06 February 2022
AEL
-
-
APOEL
09 February 2022
P.A.E.E.K.
-
-
APOEL
12 February 2022
APOEL
-
-
AEK Larnaca
17 February 2022
APOEL
-
-
Anorthosis
19 February 2022
Omonoia
-
-
APOEL
22 September 2021
APOEL
2-0
-
Nea Salamis
19 January 2022
APOEL
2-1
-
Olympiakos
02 February 2022
Olympiakos
-
-
APOEL