Matches
24 July 2021
Shakhtar Donetsk
2-1
-
Inhulets Petrove
30 July 2021
FC Lviv
0-3
-
Shakhtar Donetsk
07 August 2021
Shakhtar Donetsk
1-2
-
Olexandriya
13 August 2021
Shakhtar Donetsk
2-0
-
FC Metalist 1925 Kharkiv
21 August 2021
Chornomorets Odesa
0-3
-
Shakhtar Donetsk
29 August 2021
Minaj
1-1
-
Shakhtar Donetsk
11 September 2021
Shakhtar Donetsk
2-0
-
Dnipro-1
18 September 2021
Mariupol
0-5
-
Shakhtar Donetsk
25 September 2021
Shakhtar Donetsk
4-1
-
NK Veres Rivne
03 October 2021
Dynamo Kyiv
0-0
-
Shakhtar Donetsk
15 October 2021
Shakhtar Donetsk
6-1
-
Zorya Luhansk
23 October 2021
Vorskla
0-2
-
Shakhtar Donetsk
30 October 2021
Shakhtar Donetsk
4-1
-
Desna
07 November 2021
Kolos Kovalivka
1-3
-
Shakhtar Donetsk
20 November 2021
Shakhtar Donetsk
2-0
-
Rukh Vynnyky
28 November 2021
Inhulets Petrove
0-1
-
Shakhtar Donetsk
03 December 2021
Shakhtar Donetsk
6-1
-
FC Lviv
11 December 2021
Olexandriya
1-2
-
Shakhtar Donetsk
26 February 2022
FC Metalist 1925 Kharkiv
-
-
Shakhtar Donetsk
06 March 2022
Shakhtar Donetsk
-
-
Chornomorets Odesa
12 March 2022
Shakhtar Donetsk
-
-
Minaj
19 March 2022
Dnipro-1
-
-
Shakhtar Donetsk
02 April 2022
Shakhtar Donetsk
-
-
Mariupol
09 April 2022
NK Veres Rivne
-
-
Shakhtar Donetsk
16 April 2022
Shakhtar Donetsk
-
-
Dynamo Kyiv
23 April 2022
Zorya Luhansk
-
-
Shakhtar Donetsk
30 April 2022
Shakhtar Donetsk
-
-
Vorskla
07 May 2022
Desna
-
-
Shakhtar Donetsk