Matches
25 July 2021
Žilina
3-0
-
Sered
01 August 2021
Zlaté Moravce
0-1
-
Žilina
08 August 2021
Žilina
3-1
-
Pohronie
15 August 2021
Tatran Liptovský
2-1
-
Žilina
22 August 2021
Žilina
3-0
-
Senica
29 August 2021
Spartak Trnava
1-1
-
Žilina
11 September 2021
Žilina
1-3
-
Trenčín
19 September 2021
Slovan Bratislava
2-2
-
Žilina
25 September 2021
Žilina
0-2
-
Ružomberok
02 October 2021
Michalovce
1-0
-
Žilina
16 October 2021
Žilina
0-2
-
Dunajská Streda
22 October 2021
Sered
1-1
-
Žilina
30 October 2021
Žilina
4-1
-
Zlaté Moravce
06 November 2021
Pohronie
1-2
-
Žilina
20 November 2021
Žilina
2-2
-
Tatran Liptovský
30 November 2021
Senica
2-2
-
Žilina
05 December 2021
Žilina
0-1
-
Spartak Trnava
11 December 2021
Trenčín
1-3
-
Žilina
19 December 2021
Žilina
1-1
-
Slovan Bratislava
12 February 2022
Ružomberok
-
-
Žilina
19 February 2022
Žilina
-
-
Michalovce
26 February 2022
Dunajská Streda
-
-
Žilina
22 September 2021
(5-6)
(5-6)
TJ Jednota Bánová
0-0
-
Žilina
28 September 2021
Raven
1-2
-
Žilina
02 November 2021
Dolný Kubín
2-3
-
Žilina
02 March 2022
Žilina
-
-
KFC Komárno