Having let a lead slip late on last time out, Tottenham will look to recover against Barcelona, who began with a bang.
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Tottenham must regroup swiftly having opened Group B with a defeat, although they could scarcely face a more daunting home game than a visit from Barcelona.
• While Spurs conceded two late goals to go down 2-1 at Internazionale Milano on matchday one, Barcelona eased past PSV Eindhoven 4-0 – Lionel Messi scoring his record eighth hat-trick in the UEFA Champions League.
• The sides' only previous contests came in the 1981/82 European Cup Winners' Cup semi-finals. After a 1-1 first-leg draw at White Hart Lane, Allan Simonsen's 46th-minute goal at the Camp Nou proved enough for Barcelona to go through to the final, where they beat Standard Liège 2-1.
• Third in last season's Premier League, Tottenham are in the group stage for the fourth time – and the third season in a row.
• Spurs got to the round of 16 in 2017/18, losing to Juventus. Tottenham drew the away first leg 2-2 – having been 2-0 down – but went out after a 2-1 reverse at Wembley. The matchday three loss at Inter means they are without a win in their last three European fixtures
• Mauricio Pochettino's side won all three home games in last season's group stage, against Borussia Dortmund, Real Madrid and APOEL. Before beating Dortmund on matchday one they had won just one of their previous five European home fixtures.
• The 3-1 win against Real Madrid last season was Tottenham's first success at home to Spanish opponents in their sixth fixture (D2 L3). It was also only their second win in their 12 games against Liga clubs, home and away, and the first since a 5-1 defeat of Atlético Madrid in the 1962/63 European Cup Winners' Cup final.
• Tottenham's most successful UEFA Champions League campaign came in 2010/11, when they reached the quarter-finals.
• Spanish champions for the 25th time – and third in four years – in 2017/18, Barcelona have been European champions on five occasions, most recently in 2015.
• Barça have won their group in each of the past 11 seasons, and have reached at least the quarter-finals in all of those UEFA Champions League campaigns, both competition records. In 2017/18, they succumbed to a remarkable Roma fightback in the last eight, going out despite a 4-1 home first-leg victory after losing 3-0 in the Rome return.
• That defeat at Roma ended Barcelona's ten-match unbeaten run in the UEFA Champions League (W6 D4).
• Barcelona won only one of their three away games in last season's group stage, drawing the other two, although they kept three clean sheets. They have won five of their last 16 away matches in the competition, drawing five and losing six. They have lost four of their last nine away games in the UEFA Champions League.
• The Blaugrana's last trip to England was a 1-1 draw at Chelsea in last season's round of 16 first leg, setting up a 4-1 aggregate win. After losing 3-1 at Manchester City in the 2016/17 group stage, they are without a win in their last two visits – having won the previous three away games.
Links and trivia
• Thomas Vermaelen made 110 appearances for Tottenham's north London rivals Arsenal between 2009 and 2014, scoring 13 times. He faced Spurs six times (W4 L2).
• Have also played in England:
Philippe Coutinho (Liverpool 2013–18)
Luis Suárez (Liverpool 2011–14)
Gerard Piqué (Manchester United 2006–08)
• Suárez scored four times in seven appearances for Liverpool against Spurs.
• Fernando Llorente was a late substitute in Juventus's defeat by Barcelona in the 2015 UEFA Champions League final.
• Have played in Spain:
Fernando Llorente (Athletic Club 2004–13, Sevilla 2015/16)
Toby Alderweireld (Atlético Madrid 2013/14)
• Have played together:
Hugo Lloris & Samuel Umtiti (Lyon 2012)
Jan Vertonghen, Toby Alderweireld, Christian Eriksen, Thomas Vermaelen & Jasper Cillessen (Ajax)
• International team-mates:
Toby Alderweireld, Mousa Dembélé, Jan Vertonghen & Thomas Vermaelen (Belgium)
Hugo Lloris & Ousmane Dembélé, Samuel Umtiti (France)
• Summer transfers
Out: Keanan Bennetts (Borussia Mönchengladbach), Anton Walkes (Portsmouth), Reo Griffiths (Olympique Lyonnais), Cameron Carter-Vickers (Swansea City, loan), Marcus Edwards (Excelsior, loan), Josh Onomah (Sheffield Wednesday, loan)
• Hugo Lloris's next UEFA Champions League appearance will be his 50th.
• Spurs have kept only two clean sheets in nine matches in all competitions this season – in the 3-0 win at Manchester United on 27 August and Saturday's 2-0 success at Huddersfield.
• Harry Kane got both goals at Huddersfield, and has five goals in his first seven Premier League matches this season – only one short of his tally at the same point in 2017/18.
• Tottenham beat Watford 4-2 on penalties after a 2-2 draw in the English League Cup third round on 26 September and will travel to London rivals West Ham in round four at the end of this month.
• Moussa Sissoko and Dele Alli both returned from hamstring injuries against Watford, although the latter missed the Huddersfield game having suffered a recurrence of the injury.
• Jan Vertonghen (hamstring) and Mousa Dembélé (quad muscle) both had to be replaced at half-time on Saturday due to injury.
• Serge Aurier suffered a thigh injury against Watford, a match Christian Eriksen missed with an abdominal problem.
• On 13 September, Lloris was ruled out for "several weeks" with a thigh injury. His understudy Michel Vorm has not played since matchday one with a knee complaint.
• Summer transfers
In: Arthur (Grêmio), Clément Lenglet (Sevilla), Malcom (Bordeaux), Arturo Vidal (Bayern)
Out: Gerard Deulofeu (Watford), Andrés Iniesta (Vissel Kobe), Paulinho (Guangzhou Evergrande, loan), Douglas (Sivasspor, loan), Adriá Ortolá (Deportivo, loan), Lucas Digne (Everton), Aleix Vidal (Sevilla), Yerry Mina (Everton), André Gomes (Everton, loan), José Arnaiz (Leganés), Marlon (Sassuolo), Paco Alcácer (Dortmund, loan)
• Gerard Piqué's next appearance in the UEFA Champions League will be his 100th. He would become the tenth Spanish player to reach that mark.
• Luís Suárez made his 50th appearance in the UEFA Champions League on matchday one.
• Barcelona came from behind to beat Sevilla 2-1 in the Spanish Super Cup on 12 August, Piqué and Ousmane Dembélé with the goals.
• Ernesto Valverde's side dropped points for the first time this season after matchday one, drawing 2-2 at home to Girona on 23 September. Three days later, they were beaten 2-1 at Leganés; on Saturday they were held 1-1 at home by Athletic Club.
• Munir El Haddadi made his first league start for Barcelona since April 2016 at Leganés, when Thomas Vermaelen made his first club appearance of the season.
• El Haddadi scored Saturday's late equaliser against Athletic, his first Barcelona goal since the Spanish Super Cup in August 2016, and his first in the league for the club since March 2016.
• Barcelona last went three Liga games in a row without a win with three successive draws in November/December 2016.
• Dembélé has three goals already in the Liga this season, matching his total for the whole of last season.
• Lionel Messi has ten goals in his last 11 Liga matches, and five in seven this season.