Juventus suffered a late setback last time out but a draw against Valencia would be enough to reach the round of 16.
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Juventus will look to regroup from a late setback on matchday four as Valencia come to Turin still in contention for a place in the round of 16.
• Despite Cristiano Ronaldo's early red card, two Miralem Pjanić penalties gave Juve a 2-0 victory at Mestalla on matchday one. The Italian side are now on nine points, two ahead of Manchester United – victors at the Juventus Stadium last time out – with Valencia on five and debutants Young Boys on one.
• Juventus will be through with a draw or if Manchester United do not win at home to Young Boys. Valencia will be out of contention for a top-two finish if they do not win and United do.
• The Bianconeri kept clean sheets in winning their first three Group H games, following the success at Valencia with a 3-0 home defeat of Young Boys and a 1-0 win at Manchester United. The English club scored two late goals in Italy to win 2-1, however, as Juve missed the chance to seal their place in the round of 16 with two games to spare despite Ronaldo's first UEFA Champions League goal for the club.
• Juventus claimed their seventh successive Serie A title in 2017/18, and are in the UEFA Champions League group stage for the 19th time overall. They last failed to reach the round of 16 in 2013/14.
• In last season's UEFA Champions League, Juve finished second to Barcelona in their section before ousting Tottenham in the round of 16 (2-2 home, 2-1 away). Elimination beckoned when they went down 3-0 at home to Real Madrid in the quarter-final first leg – a repeat of the 2017 final, won 4-1 by the Spanish side – only for Juve to score three times in the return. Ronaldo, however, had the last word against his current club, converting a penalty deep into added time to end Juve's campaign.
• That defeat by Madrid ended Juve's 27-game unbeaten home run in UEFA competition (W16 D11), dating back to a 2-0 reverse against Bayern München in April 2013. The loss to United on matchday four was only their third European defeat in 35 matches at the Juventus Stadium (W20 D12) – but the second in the last three.
• Juve picked up seven points at home in last season's group stage, beating Olympiacos 2-0 and Sporting CP 2-1 and drawing with Barcelona (0-0). The win against Young Boys on matchday two ended a three-match run without a European win in Turin (D2 L1).
• The defeat by Madrid ended Juve's nine-match unbeaten run (W5 D4) at home to Spanish clubs, stretching back to March 2004.
• Winners in 1985 and 1996, Juventus have played in nine European Cup finals – losing a record seven, including all of their last five.
• Valencia responded to losing to Juve by holding out for a goalless draw at Manchester United in their second match. They drew their next away game too, 1-1 at Young Boys, before beating the Swiss side 3-1 in the home match.
• The United draw ended Los Blanquinegros' four-game losing streak in the UEFA Champions League. They were without a goal in five matches before scoring in both fixtures against Young Boys.
• Valencia have won three of their last nine UEFA Champions League away matches, qualifying included (D3 L3), but none of the last four (D2 L2).
• Fourth in the Spanish Liga in 2017/18, this is Valencia's 11th UEFA Champions League group stage campaign. Finalists in both 1999/2000 and 2000/01, they have not reached the last 16 since 2012/13.
• Valencia did not take part in UEFA club competition in either of the last two seasons. In their most recent campaign, 2015/16, they finished third in their UEFA Champions League section to move into the UEFA Europa League, where they beat Rapid Wien 10-0 on aggregate in the round of 32 before losing on away goals to fellow Spanish side Athletic Club in the round of 16 (0-1 away, 2-1 home).
• Before matchday one, Valencia had not played Italian opposition since the 2009/10 UEFA Europa League group stage, beating Genoa 3-2 at home and 2-1 away. David Villa scored a late winner in each instance.
• That win in Genoa was just Valencia's second in their 11 trips to Italy (D3 L6).
Links and trivia
• Ronaldo played for Madrid between 2009 and joining Juventus this summer, scoring 311 goals in 292 matches; that included 15 goals in 18 appearances against Valencia.
• Valencia goalkeeper Neto made 11 Serie A appearances for Juventus between 2015 and 2017, having featured 72 times in the league for Fiorentina from 2011 to 2015.
• João Cancelo scored twice in 72 Liga outings for Valencia between 2014 and 2017.
• Sami Khedira was a Real Madrid player from 2010 to 2015, winning the Liga in 2011/12 and the UEFA Champions League two years later.
• Has also played in Spain:
Mario Mandžukić (Atlético Madrid 2014/15)
• Has also played in Italy:
Cristiano Piccini (Fiorentina 2010/11, Carrarese 2011/12 loan, Spezia 2012/13 loan, Livorno 2013/14)
Jeison Murillo (Internazionale 2015–17)
Geoffrey Kondogbia (Internazionale 2015–17)
• Have played together:
Blaise Matuidi & Gonçalo Guedes (Paris Saint-Germain, 2016/17)
Blaise Matuidi & Kévin Gameiro (Paris 2011–13)
Cristiano Ronaldo & Ezequiel Garay (Real Madrid 2009–11)
Sami Khedira & Ezequiel Garay (Real Madrid 2010/11)
Cristiano Ronaldo & Denis Cheryshev (Real Madrid 2015/16)
• International team-mates:
Juan Cuadrado & Jeison Murillo (Colombia)
Blaise Matuidi & Geoffrey Kondogbia (France)
Cristiano Ronaldo, João Cancelo & Gonçalo Guedes (Portugal)
• Juventus recovered from their home defeat against United by winning 2-0 at AC Milan. Their tally of 37 points is the highest ever in Serie A after 13 games. The Bianconeri have earned 12 wins and a draw this season, beating SPAL 2-0 on Saturday.
• Juve's winning start to the season was ended by a 1-1 home draw against Genoa on 20 October, the only Serie A game they have failed to win since 13 May.
• The Genoa draw is the only time Juve have failed to score two goals or more in Serie A this season.
• Juve have lost only once in their last 38 Serie A matches, winning 32.
• Juve have won their last five UEFA Champions League away games and all six away Serie A matches this season. The Bianconeri have not lost an away game in Serie A since a 3-2 reverse at Sampdoria on 19 November 2017.
• Cristiano Ronaldo has nine goals and five assists in his last ten Serie A appearances, including Saturday's goal against SPAL.
• Giorgio Chiellini won his 100th cap for Italy in the 0-0 draw against João Cancelo's Portugal on 17 November, the result taking the visitors into the Finals at the expense of the Azzurri.
• Federico Bernardeschi withdrew from the Italy squad after suffering a thigh injury in training, and missed the SPAL game.
• Miralem Pjanić also returned early from international duty after suffering a slight thigh injury in the 0-0 UEFA Nations League draw between Austria and his Bosnia and Herzegovina side, the result meaning the Bosnians won promotion to League A. Pjanić played 90 minutes against SPAL.
• Moise Kean scored in a 2-1 defeat for Italy's Under-21 side against England on 15 November. He made his senior debut in the 1-0 friendly against the United States five days later, becoming the first Italian international born this century.
• Paulo Dybala scored his first international goal for Argentina in a 2-0 victory against Mexico on 20 November.
• Emre Can is sidelined by a thyroid problem that required surgical treatment.
• Sami Khedira was out between matchday one and matchday four with a thigh injury and subsequently twisted his left ankle in training.
• Full-back Leonardo Spianazzola was not included in the UEFA Champions League squad as he is recovering from knee surgery.
• Medhi Benatia has been named on a five-man shortlist for the BBC African Footballer of the Year award.
• Ronaldo's overhead kick for Real Madrid against his current club Juventus in last season's UEFA Champions League quarter-final first leg was voted UEFA.com Goal of the Season.
• Before beating Ebro 2-1 in the Copa del Rey on 30 October Valencia had won only once in 13 matches this season (D10 L2), drawing five in a row before that match; they have now won four of their last five fixtures, beating Rayo Vallecano 3-0 on Saturday.
• A 1-0 win against Getafe on 10 November was only Valencia's second Liga success this season.
• The Spanish side have lost only one of their 13 matches since the matchday one defeat at home to Juventus (W5 D7).
• Valencia have 17 points after 13 games in the new Liga season – 14 fewer than at the same stage of 2017/18.
• Santi Mina, who was out between 23 September and 30 October with a knee injury, has six goals in his last five Valencia appearances, including two on Saturday.
• Michy Batshuayi scored twice in Belgium's 2-0 UEFA Nations League win against Iceland on 15 November.
• Denis Cheryshev was replaced early in the first half of the 1-1 draw against Leganés on 20 October with a hamstring problem and has not featured since.
• Cristiano Piccini (calf) has not played since matchday three.