Newcastle held but still progress

Newcastle United FC 0–0 FK Ventspils (agg: 1-0)
Newcastle had to rely on Titus Bramble's goal from the first leg as they went through with a 0-0 draw in front of their home fans. Newcastle winger Damien Duff tormented the visitors and could have scored on several occasions, but missed the chances and nobody was on hand to convert the other opportunities that he created. James Milner went closest to scoring against the Latvian club when he thumped the crossbar with a curling effort from a free-kick 25 metres out.

Drogheda United 1-0 IK Start (agg: 1-1; Start win 11-10 on pens)
Start came out on top against Drogheda United FC but only after an epic penalty shoot-out in Dublin which saw Graham Gartland miss twice from the spot. The sides were deadlocked after 90 minutes of normal time, a header by Irish Under-21 international Eamon Zayed bringing the home side level on aggregate. A further 30 minutes of extra time could not separate the sides so the tie went to penalties. Gartland missed his kick for Drogheda but his pain was initially spared when Alex Valencia also missed. However, after eleven spot-kicks each, the two sides had to start all over, with Gartland missing again and Stefan Barllin this time punishing him to seal qualification for the visitors.

Llanelli AFC 1–5 Odense BK (agg: 1-6)
The Welsh hosts made a storming start and midfielder Antonio Corbisiero quickly brought the scores level on aggregate before Craig Williams shot against the crossbar. However, OB stepped up the pace as Mads Timm and Esben Hansen scored to put them well in control before the break. The visitors continued to dominate in the second half and scored again through Anders Christensen, Jan Tore Ophaug and Bechara.

FBK Kaunas 1–0 Randers FC (agg: 2-3)
The Lithuanian side went down fighting but could not overcome a 3-1 first-leg deficit against Randers. Andrius Velicka forced Martin Jensen into a first-half save and shot wide ten minutes into the second period as the home team pushed forward. Randers's Kenneth Pedersen was then dismissed for a foul on Arkadiusz Klimek in the penalty area. Velicka converted from the spot but they could not find the winning goal amid a torrential downpour.

FC Levadia Tallinn 1–0 FC Twente (agg: 2-1)
Levadia became the first Estonian side to successfully pass through two rounds of a European club competition as they earned a shock win. Twente's Kennedy Bakircioglü had a shot deflected on to the crossbar after 28 minutes before Konstantin Nahk beat Twente goalkeeper Sander Boschker with a superb free-kick after 36 minutes. The Dutch side failed to make pressure count and found that Artur Kotenko’s goal led a charmed life.

Åtvidabergs FF 1-1 SK Brann (agg: 4-4, Åtvidabergs win on away goals)
Second division outfit Åtvidabergs are Sweden's only remaining representative in European competition after qualifying for the next round of the tournament on the away-goals rule following this well-earned draw. A trademark goal by physiotherapist Mats Haglund gave the Swedish part-timers the lead after 34 minutes and the home side held on until five minutes from time when their stubborn defence was breached by Björn Dahl's header. Brann went all out in search of the crucial winning goal and the tactic almost paid off only for Dahl's 93rd minute header to rebound back off the post.

Skonto FC 1–2 Molde FK (agg: 1-2)
Skonto failed to make the best of a goalless first leg in Norway as Molde won 2-1 in Riga. The Latvian side made an aggressive start with Molde happy to hit them on the break. However, as Skonto's energy dipped, the visitors took the lead with Matej Mavrič heading a 41st-minute corner past Andrejs Piedels. It was 2-0 after 61 minutes as Stian Ohr beat Piedels after a fine ball from Magne Hoseth. Skonto captain Vitalijs Astafjevs pulled one back from another corner.

Brøndby IF 4-0 FC Flora (agg: 4-0)
Brøndby have their young guns to thank for sending them through following this impressive performance. The 17-year-old Nikolaj Agger scored twice, while 18-year-old Mike Jensen and Kasper Lorentzen (20) were also on the scoresheet in a convincing victory. The home side did not get into their stride until after the break when half-time substitute Mike Jensen broke the deadlock on 49 minutes, latching on to a fine through ball by Martin Ericsson. In the 63rd minute, Agger made it 2-0, with Ericsson again the provider and with 15 minutes to go, Lorentzen caught the Flora defence off-guard to put the result beyond doubt. Three minutes later, Agger scored his second of the evening, dribbling past Flora goalkeeper Pavel Londak to complete a comfortable win.

Club Brugge KV 5–2 FK Sūduva (agg: 7-2)
Club Brugge stormed through to the first-roundafter a goal-packed night in Belgium. Kevin Roelandts and Boško Balaban scored before the interval to kill the tie off as a contest but Sūduva showed spirit, levelling the scores on the night with an Otavio Braga header and a David Chigladze penalty. The home side restored their lead as Ivan Gvozdenović scored and then set up Grégory Dufer to make it 4-2. Balaban scored a fifth with a sweet free-kick before Sūduva's Karolis Jasaitis was sent off for a second bookable offence.

Derry City FC 2–2 Gretna FC (agg: 7-3)
David Graham's goal from distance early on gave the Scottish side hopes of an unlikely recovery from a 5-1 first leg deficit at Derry, but Mark Farren's equaliser just before half-time effectively ended their prospects. Ken Oman put Derry ahead in the 69th minute following a goalmouth scramble before Gretna substitute Ryan Baldacchino equalised on the night for a respectable draw.