Shared history in Monaco, Ricardo Quaresma's return, Klaas-Jan Huntelaar targets exclusive club and Pepe Reina set to equal Roberto Carlos – matchday two highlights.
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Huntelaar eyes exclusive goal club
Klaas-Jan Huntelaar, who has struck five in eight outings for the Royal Blues this term, can join an exclusive club featuring the likes of Cristiano Ronaldo, Lionel Messi and Raúl González by registering against Asteras in Gelsenkirchen. Two more goals and the Dutch marksman will reach 50 in UEFA club competition – matching Alfredo Di Stéfano and Didier Drogba's European hauls. It would be fitting if a forward who once likened scoring goals to "riding a bike – you never forget", attains a mark that just 13 other players have achieved.
Schalke v Asteras – 19.00CET
Close links bind rivals
Monaco and Tottenham have met once before, the French side beating André-Villas Boas's Spurs 5-2 in an August 2013 friendly – notable less for Radamel Falcao's two goals than for the fact Gareth Bale was absent, negotiating his move to Real Madrid. However, the two clubs' connections run deeper than that, with some notable former players in common: Dimitar Berbatov, Jürgen Klinsmann, Emmanuel Adebayor and Glenn Hoddle.
Monaco v Tottenham – 19.00CET
Sion seek change of fortune at Anfield
"We are such a talented bunch when we have to chase things," remarked then Liverpool boss Roy Evans as the Reds recovered from going 2-0 behind in the second leg of their 1996/97 UEFA Cup Winners' Cup second round return leg at Anfield to fell Sion 6-3. Kopites remember the game for a terrific Robbie Fowler goal but, ahead of the rematch, the Swiss can take courage from the fact they were the first visiting side to score three at Anfield in a UEFA tie.
Liverpool v Sion – 21.05CET
Bordeaux's primed for long-range effort
Having already undertaken a round trip of about 12,000km to overcome Kairat Almaty in the play-offs – the longest journey in UEFA club competition history – Bordeaux's 3,650km voyage to Kazan to play Rubin is apparently no big deal. "It will be a few more hours on a plane," said coach Willy Sagnol with a shrug. "We are used to it now."
Rubin v Bordeaux – 21.05CET
Çiftçi gives Celtic inside scoop
Celtic may have some inside knowledge for their first encounter with Turkish opposition in Fenerbahçe, with Nadir Çiftçi itching for action following his summer arrival from Dundee United. "Nadir is quite loud and quite annoying, but it is good to have another one of these guys in the changing room," winger Gary Mackay-Steven said of the former Kayserispor man. "You need to keep your eye on him because he's a big character on and off the field. He's not shy. He came in and on the first day he was pleasant and quiet, but now he has come out of his shell."
Celtic v Fenerbahçe – 21.05CET
Reina to set new mark in Warsaw
Still just 33 – no great age for a goalkeeper – Pepe Reina has been glowing since returning to Napoli, where he spent 2013/14 on loan, from Bayern München in June. "Napoli means happiness, that's why I decided to come back," he said upon signing. "Napoli fans live and breathe football and I'm proud to wear this shirt again." Should he play at Legia, the Spaniard will move onto 144 UEFA club appearances – level with Roberto Carlos in ninth place in the all-time standings.
Legia v Napoli – 21.05CET
Pogba can profit from Olimpico inside info
Saint-Étienne coach Christophe Galtier said he was "delighted to be playing in a stadium like the Olimpico" as his team prepared to visit Lazio – and it will only take a quick phone call from Les Verts defender Florentin Pogba to gen up on how it feels to win there. In the space of the last 12 months his younger brother Paul Pogba has scored twice at Lazio in a 3-0 Juventus victory in Serie A, then celebrated winning the Coppa Italia following a 2-1 final triumph over the Biancocelesti at the Rome venue.
Lazio v St-Étienne – 19.00CET
Sporting graduate Quaresma returns home
Winger Ricardo Quaresma was enthusiastic about the regime at Sporting when he spoke to Portuguese radio, saying: "Sporting are stronger with Jorge Jesus. He has proved that he's a great coach and I believe he will do a great job." However, the one-time 'Harry Potter' of Portuguese football will hope his first club have an off-night as he meets Sporting for the first time as a Beşiktaş player. The Black Eagles' task will be made harder with Under-21 international William Carvalho back for the visitors after recovering from a stress fracture.
Beşiktaş v Sporting CP – 19.00CET
Watertight Plzeň visit the Yellow Submarine
Since replacing Miroslav Koubek on 16 August, Karel Krejčí has turned the Czech title holders into daunting opponents – Viktoria only conceded for the first time in eight wins under their new coach on Saturday in beating Slovan Liberec 2-1. However, Villarreal found the net at least once in all 12 of their European matches last season: 29 goals in total.
Villarreal v Plzeň – 21.05CET