Tottenham hold the advantage in the all-Premier League quarter-final as they travel to Manchester City defending a 1-0 lead.
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For the second season running Manchester City must try to overturn an away first-leg defeat against a fellow Premier League club in the UEFA Champions League quarter-finals as Tottenham come to north-west England holding a slender advantage.
• City missed the chance to strike first in the opening leg on 9 April – Spurs' first European game at their new ground – when Sergio Agüero had a first-half penalty saved by Hugo Lloris. That proved costly when Heung-Min Son scored what proved the only goal with 12 minutes remaining, meaning City have now lost all five of their games against English clubs in UEFA competition.
• This is City's third last-eight tie in the past four seasons – and a second successive contest at this stage against a fellow English club – while Spurs are in the UEFA Champions League quarter-finals for the first time since their sole previous appearance eight years ago.
• Both produced positive round of 16 performances against German opponents, Spurs seeing off Borussia Dortmund 4-0 on aggregate while City recorded their biggest European victory in the last-16 second leg, dismantling Schalke 7-0 in Manchester to complete a 10-2 success over the two matches.
• There has been very little between Tottenham and City over the years. In 157 competitive meetings, both have now recorded 61 wins with 35 draws – although City had won three in a row before the first-leg defeat in this tie.
• In this season's Premier League, a sixth-minute Riyad Mahrez goal proved enough for City to pick up three points against Spurs at Wembley on 29 October. The league game at the City of Manchester Stadium is scheduled for 20 April – three days after this match.
• In English domestic knockout football, Spurs have won nine of the teams' 14 ties – including five of the last six.
• City's record in European Cup quarter-finals is W1 L1:
2017/18 Liverpool L 1-5 (0-3 a, 1-2 h)
2015/16 Paris Saint-Germain W 3-2 (2-2 a, 1-0 h)
• City have now played five games against English clubs in European competition, and lost them all. Indeed, Gabriel Jesus's early goal in the quarter-final second leg against Liverpool 12 months ago is the only one they have managed in those five fixtures, with eight conceded.
• In addition to last season's defeat by Liverpool, City were also beaten by eventual winners Chelsea in the 1970/71 European Cup Winners' Cup semi-finals, losing 1-0 both away and at home.
• City's best UEFA Champions League performance was reaching the 2015/16 semi-finals.
• The winners of Group F in the autumn, City are in the knockout stages for the sixth year in a row, although this is only the third time they have made it to the last eight.
• City have twice recorded their biggest European victory in this season's UEFA Champions League, beating Shakhtar Donetsk 6-0 in Manchester on matchday four before the 7-0 defeat of Schalke in the round of 16 second leg.
• The English champions opened this season with an unexpected 2-1 loss at home to Lyon – their third successive European defeat in Manchester, all by the same scoreline – but won six of their next seven fixtures before losing at Spurs.
• Josep Guardiola's side have won seven of their last 14 European matches, home and away – losing six.
• City have scored 16 goals in their four home games in this season's competition.
• City have won only two of the seven UEFA competition ties in which they lost the away first leg – and have lost the last five such ties on aggregate, most recently against Liverpool at this stage last season. They have lost two of the three ties in which they were defeated 1-0 away in the first leg – that 1970/71 European Cup Winners' Cup semi-final against Chelsea and, most recently, on away goals against Sporting CP in the 2011/12 UEFA Europa League round of 16 (3-2 home).
• Indeed, the Citizens have not won a tie on aggregate after an away first-leg loss since beating Górnik Zabrze in the 1970/71 European Cup Winners' Cup quarter-finals, and even then they needed a replay after each side won 2-0 at home; City were 3-1 victors in the third game.
• City's record in two UEFA penalty shoot-outs is W2 L0:
4-3 v Aalborg, 2008/09 UEFA Cup round of 16
4-2 v Midtjylland, 2008/09 UEFA Cup second qualifying round
• Tottenham have won one and lost one of their previous two European Cup quarter-finals:
2010/11 Real Madrid L 0-5 (0-4 a, 0-1 h)
1961/62 Dukla Praha W 4-2 (0-1 a, 4-1 h)
• This is Spurs' fourth all-English European tie, but a first in 46 years, since an away-goals defeat by Liverpool in the 1972/73 UEFA Cup semi-final (0-1 a, 2-1 h). That made Spurs' two-legged record against English clubs W1 L2.
• Tottenham did win a European trophy at the expense of domestic opponents, overcoming Wolverhampton Wanderers 3-2 on aggregate (2-1 away, 1-1 home) in the first UEFA Cup final in 1972.
• The 1-0 win at Dortmund in the round of 16 second leg means Tottenham's away record in the UEFA Champions League knockout rounds is W2 D1 L1.
• This season, Mauricio Pochettino's side picked up only two points on their travels in Group B, losing 2-1 at Inter before draws at PSV Eindhoven (2-2) and Barcelona (1-1). The latter result, on matchday six, helped them overtake Inter to snatch second place behind Barça; Spurs had only one point after three matches.
• The Lilywhites have won just five of their last 19 European away matches (D7 L7).
• Tottenham have won 17 of the 19 ties in UEFA competition in which they won the home first leg, most recently against Borussia Dortmund in this season's round of 16. Spurs' last aggregate defeat when winning in the home first leg came after an initial 1-0 success, however, against Kaiserslautern in the 1999/2000 UEFA Cup second round (0-2 away); their overall record after a 1-0 home first-leg win is W1 L1.
• Tottenham's record in three UEFA penalty shoot-outs is W1 L2:
1-4 v Basel, 2012/13 UEFA Europa League quarter-final
5-6 v PSV Eindhoven, 2007/08 UEFA Cup round of 16
4-3 v Anderlecht, 1983/84 UEFA Cup final
Links and trivia
• The first leg was only City manager Guardiola's third defeat in his 15 managerial contests with Mauricio Pochettino (W8 D4); the pair also crossed paths as coaches in Spain with Barcelona and Espanyol respectively.
• Kyle Walker was a Tottenham player between 2011 and signing for City in 2017, scoring four goals in 183 Premier League appearances for the Lilywhites.
• Kieran Trippier joined City's academy aged nine and stayed until 2012, when he departed for Burnley on a permanent deal having failed to make a first-team appearance.
• International team-mates:
John Stones, Kyle Walker, Fabian Delph, Raheem Sterling & Eric Dier, Danny Rose, Kieran Trippier, Dele Alli, Harry Kane (England)
Vincent Kompany, Kevin De Bruyne & Toby Alderweireld, Jan Vertonghen (Belgium)
Ederson, Danilo, Fernandinho, Gabriel Jesus & Lucas Moura (Brazil)
Nicolás Otamendi, Sergio Agüero & Paulo Gazzaniga, Juan Foyth, Erik Lamela (Argentina)
Benjamin Mendy & Hugo Lloris (France)
• Lloris and Mendy were both members of France's victorious 2018 FIFA World Cup squad.
• City are the top scorers in this season's UEFA Champions League with 26 goals.
• The first leg was only City's second defeat in their last 25 games in all competitions (W22) – they have scored 75 goals in that run, conceding only 13. They were 3-1 winners at Crystal Palace on Sunday.
• The one game in that sequence that City drew was against Chelsea in the League Cup final at Wembley on 24 February; they went on to win 4-3 on penalties to lift the trophy for the sixth time overall and the fourth in the last six seasons.
• Raheem Sterling, who scored twice at Palace, has six goals in his last seven City appearances and nine in his last nine for club and country.
• City have reached the FA Cup final for the first time since 2013 – and the 11th overall – and will play Watford in the final at Wembley on 18 May.
• The English champions have won their last nine league matches.
• City's home record in all competitions this season is W23 L2 – they have won the last 11, scoring 48 goals and conceding three while keeping eight clean sheets.
• City have kept seven clean sheets in their last 11 matches in all competitions.
• Josep Guardiola's side have scored five or more goals in ten of their 54 games this season.
• The Manchester club beat third-tier Burton Albion 9-0 at home in the first leg of the League Cup semi-final on 9 January – City's biggest win since a 10-1 defeat of Huddersfield in 1987. They won the return leg 1-0.
• The Citizens signed 18-year-old midfielder Ante Palaversa from Hajduk Split in January, loaning the teenager back to the Croatian club for the rest of the season.
• Sergio Agüero has four goals in his last five matches and 15 in his last 16.
• Bernardo Silva missed the first leg against Spurs with a muscle injury, returning as a second-half substitute on Sunday.
• Oleksandr Zinchenko went off midway through the first half against Cardiff on 2 April with a hamstring problem.
• Benjamin Mendy had surgery on the cartilage in his left knee on 14 November. Until he played 79 minutes in the FA Cup semi-final against Brighton on 6 April his only appearance since then had been in the second leg at Burton on 23 January; he played 90 minutes at Palace.
• Claudio Bravo has been out since sustaining an Achilles problem on 20 August.
• Heung-Min Son made his 50th appearance in UEFA club competition in the first leg, a mark Harry Kane will reach with his next appearance.
• Tottenham had won only once in six matches (D1 L4) before beating Crystal Palace 2-0 in the first game at their new stadium on 3 April. Spurs have won only four of their last nine matches – all those defeats coming away from home.
• The Lilywhites made it three wins from three at their new home, and three clean sheets, with a 4-0 defeat of Huddersfield on Saturday, Lucas Moura scoring a hat-trick. It was Tottenham's biggest win since a 7-0 FA Cup success at fifth-tier Tranmere on 4 January.
• Spurs have drawn only four of their 49 games in 2018/19 in all competitions (W30 L14).
• Mauricio Pochettino's side have kept six clean sheets in their last 17 fixtures.
• Harry Kane was taken off in the first leg with what Spurs described as "a significant lateral ligament injury" to his left ankle, while Dele Alli broke two bones in his left hand in the same game; neither played at the weekend.
• Fernando Llorente was replaced late on against Huddersfield due to a knock; Harry Winks missed that match with a minor groin problem.
• Serge Aurier has not played since suffering a hamstring injury in Ivory Coast's 3-0 Africa Cup of Nations qualifying win against Rwanda on 23 March.
• Eric Dier was forced off early in England's 5-0 UEFA EURO 2020 qualifying win against the Czech Republic on 22 March with a hip injury and has not featured since.
• Erik Lamela, who has not played since the round of 16 second leg at Borussia Dortmund, has a hamstring injury.