Luke Shaw's own goal means that Manchester United must try to recover from a home first-leg defeat again as they travel to Barcelona.
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For the second UEFA Champions League tie running Manchester United face an away second leg having been beaten at home as Ole Gunnar Solskjær returns to the scene of his most famous triumph with Barcelona holding the upper hand.
• An early own goal from United defender Luke Shaw – the 14th Barcelona have benefited from in the UEFA Champions League, equalling the competition record – proved enough to separate the teams at Old Trafford. It was Barcelona's first win in seven away knockout games (D2 L4) and only their second goal in that period.
• While the Catalan giants have won the last three meetings between the sides, a run that includes the UEFA Champions League finals of 2009 and 2011, United have won both previous two-legged contests.
• United produced a memorable away display to retrieve their round of 16 tie against Paris Saint-Germain and reach the quarter-finals for the first time since 2013/14. Barcelona ultimately cruised through their last-16 contest against Lyon en route to an unprecedented 12th successive last-eight appearance – although their last three UEFA Champions League campaigns have all ended at this stage.
• United won their second European Cup at the Camp Nou, coming from a goal down to beat Bayern München 2-1 in the 1999 final with two added-time goals – substitute Solskjær scoring the winner.
• While there is little between the sides overall, United recording three victories to Barcelona's five in their 12 meetings, the Spanish side have won the last three fixtures – the first two on the biggest club stage of all.
• The 2009 UEFA Champions League final in Rome went Barça's way thanks to a goal in each half from Samuel Eto'o and Lionel Messi. Two years later, Messi scored in between goals from Pedro Rodríguez and David Villa as Barcelona ran out 3-1 victors at Wembley, Wayne Rooney with United's only response.
• Gerard Piqué and Sergio Busquets joined Messi in Barcelona's line-up for both finals with United coach Michael Carrick in the opposing team for both games and Antonio Valencia appearing in 2011, when Chris Smalling was an unused substitute.
• United did get the better of Barcelona in the 2007/08 UEFA Champions League semi-finals, Paul Scholes scoring the only goal of the tie in the Old Trafford second leg after United's Cristiano Ronaldo had missed an early penalty at the Camp Nou.
• Barça have never lost at home to United (W2 D2), although the last two fixtures have both been draws.
• Barcelona inflicted United's heaviest UEFA Champions League defeat, a 4-0 reverse at the Camp Nou in the 1994/95 group stage in which Hristo Stoichkov scored twice.
• United beat Barcelona in the 1991 European Cup Winners' Cup final in Rotterdam, former Barça striker Mark Hughes scoring both goals in a 2-1 win.
• Barcelona's record in European Cup quarter-finals is W14 L6, with four of those defeats coming in the past five ties:
2017/18 Roma L 4-4 away goals (4-1 h, 0-3 a)
2016/17 Juventus L 0-3 (0-3 a, 0-0 h)
2015/16 Atlético Madrid L 2-3 (2-1 h, 0-2 a)
2014/15 Paris Saint-Germain W 5-1 (3-1 a, 2-0 h)
2013/14 Atlético Madrid L 1-2 (1-1 h, 0-1 a)
2012/13 Paris Saint-Germain W 3-3, away goals (2-2 a, 1-1 h)
2011/12 AC Milan W 3-1 (0-0 a, 3-1 h)
2010/11 Shakhtar Donetsk W 6-1 (5-1 h, 1-0 a)
2009/10 Arsenal W 6-3 (2-2 a, 4-1 h)
2008/09 Bayern München W 5-1 (4-0 h, 1-1 a)
2007/08 Schalke W 2-0 (1-0 a, 1-0 h)
2005/06 Benfica W 2-0 (0-0 a, 2-0 h)
2002/03 Juventus L 2-3 (1-1 a, 1-2 h aet)
2001/02 Panathinaikos W 3-2 (0-1 a, 3-1 h)
1999/00 Chelsea W 6-4 (1-3 a, 5-1 h aet)
1994/95 Paris Saint-Germain L 2-3 (1-1 h, 1-2 a)
1985/86 Juventus W 2-1 (1-0 h, 1-1 a)
1974/75 Åtvidaberg W 5-0 (2-0 h, 3-0 a)
1960/61 Spartak Hradec Králové W 5-1 (4-0 h, 1-1 a)
1959/60 Wolverhampton Wanderers W 9-2 (4-0 h, 5-2 a)
• Twelve months ago Barcelona looked set for the semi-finals after a 4-1 home win against Roma, only for a 3-0 away defeat to end their campaign on away goals and inflict a third successive last-eight loss. Barcelona won the home leg in two of those three ties, drawing the other.
• Barcelona have encountered English opponents already this season, taking four points off Tottenham Hotspur in the group stage thanks to a 4-2 away success and a 1-1 home draw on matchday six.
• The first-leg win made it one defeat in their last 14 European games against English clubs for Barça, who have won ten of those fixtures. They beat Chelsea 4-1 on aggregate in last season's round of 16 (1-1 away, 3-0 home).
• Their overall home record against English clubs is W20 D11 L2. They have been victorious in seven of the last nine at the Camp Nou (D2).
• Barcelona have won 14 of their 24 two-legged ties with English clubs. The 2012 semi-final defeat by Chelsea is the only reverse in their last eight contests, all in the UEFA Champions League knockout phase.
• That defeat at Roma is Barcelona's sole loss in their last 20 UEFA Champions League fixtures (W12 D7). They beat Lyon 5-1 at home in the second leg of this season's round of 16 and by the same aggregate scoreline.
• Barcelona won both home games in last season's knockout rounds, and are unbeaten in 12 knockout games at the Camp Nou (W10 D2), since a 3-0 loss to Bayern München in the 2012/13 semi-final second leg.
• Ernesto Valverde's side won their first two home games in this season's group stage, beating PSV Eindhoven 4-0 and Internazionale 2-0 before a 1-1 draw with Tottenham.
• Barcelona are unbeaten in 30 UEFA Champions League home matches, a run that started in September 2013 (W27 D3); the defeat of Lyon eclipsed the previous competition record of 29 set by Bayern München between March 1998 and April 2002.
• Barcelona need four more goals to score 500 in the UEFA Champions League – a milestone reached by just one other club, Real Madrid.
• Spanish champions for the 25th time – and third in four years – in 2017/18, Barcelona have been European champions on five occasions, most recently in 2015.
• Barcelona have progressed 36 out of the 38 times they won the away first leg in UEFA competition, most recently against Arsenal in the 2015/16 round of 16. One of those two failures came after a 1-0 away win, against Köln in the 1980/81 UEFA Cup second round (0-4 home); the other was against Metz in the 1984/85 European Cup Winners' Cup first round (4-2 away, 1-4 home). Seven of those aggregate victories came after a 1-0 first-leg away win, most recently against Schalke in the 2007/08 UEFA Champions League quarter-final.
• Barcelona's record in six UEFA penalty shoot-outs is W5 L1:
5-4 v Lech Poznań, 1988/89 European Cup Winners' Cup second round
0-2 v Steaua, 1985/86 European Champion Clubs' Cup final
5-4 v IFK Göteborg, 1985/86 European Champion Clubs' Cup semi-final
4-1 v Anderlecht, 1978/79 European Cup Winners' Cup second round
3-1 v Ipswich Town, 1977/78 UEFA Cup third round
5-4 v AZ Alkmaar, 1977/78 UEFA Cup second round
• United's record in European Cup quarter-finals is W12 L6:
2013/14 Bayern München L 2-4 (1-1 h, 1-3 a)
2010/11 Chelsea W 3-1 (1-0 a, 2-1 h)
2009/10 Bayern München L 4-4 away goals (1-2 a, 3-2 h)
2008/09 Porto W 3-2 (2-2 h, 1-0 a)
2007/08 Roma W 3-0 (2-0 a, 1-0 h)
2006/07 Roma W 8-3 (1-2 a, 7-1 h)
2002/03 Real Madrid L 5-6 (1-3 a, 4-3 h)
2001/02 Deportivo La Coruña W 5-2 (2-0 a, 3-2 h)
2000/01 Bayern München L 1-3 (0-1 h, 1-2 a)
1999/2000 Real Madrid L 2-3 (0-0 a, 2-3 h)
1998/99 Internazionale W 3-1 (2-0 h, 1-1 a)
1997/98 Monaco L 1-1 away goals (0-0 a, 1-1 h)
1996/97 Porto W 4-0 (4-0 h, 0-0 a)
1968/69 Rapid Wien W 3-0 (3-0 h, 0-0 a)
1967/68 Górnik Zabrze W 2-1 (2-0 h, 0-1 a)
1965/66 Benfica W 8-3 (3-2 h, 5-1 a)
1957/58 Crvena zvezda W 5-4 (2-1 h, 3-3 a)
1956/67 Athletic Club W 6-5 (3-5 a, 3-0 h)
• United's first 12 UEFA Champions League quarter-finals all came with Sir Alex Ferguson as manager; their most recent, the 2014 defeat by Bayern, was overseen by David Moyes.
• United engineered a stunning turnaround in the round of 16, overturning a 2-0 home defeat against Paris Saint-Germain with a 3-1 win in France to progress on away goals – only the fourth time a team had come back from losing the home first leg in the UEFA Champions League era and the first to do so following a two-goal first-leg loss.
• The Red Devils have already played Spanish opposition in this season's competition, following a goalless draw at home to Valencia on matchday two with a 2-1 loss at Mestalla in their final group game.
• This season's results against Valencia and Barcelona mean United have now won just two of their last 16 matches against Spanish clubs (D6 L8) – and none of the last seven (D3 L4). United have, however, lost only twice in their last ten visits to Spain (W2 D6).
• In 2017/18 United's campaign was ended by Spanish opponents, Sevilla winning 2-1 in the round of 16 second leg at Old Trafford to progress by the same aggregate scoreline.
• United's record in two-legged ties against Spanish clubs is W6 L8.
• United won their first two away matches in Group H this season, at Young Boys (3-0) and Juventus (2-1), before losing at Valencia. They have been beaten in only two of their last 13 European away games (W8 D3), with just eight goals conceded during that period; the Valencia contest is the only time they shipped more than one in that sequence.
• Nevertheless, United have lost just seven of their last 29 European matches, home and away (W17 D5); the losses to Valencia and Paris were the first time they have suffered successive defeats since November/December 2012.
• The round of 16 was Solskjær's first tie in the UEFA Champions League proper as a coach; he oversaw eight qualifiers while in charge of Molde (W3 D4 L1). He took the Norwegian club into the UEFA Europa League group stage in 2012/13, and into the round of 32 of that competition three years later.
• The last-16 tie against Paris was the first time United had come back from a first-leg home defeat to win the tie in UEFA competition, after three previous defeats. Two of those aggregate losses came after a 1-0 first-leg reverse, against Bayern München in the 2000/01 quarter-finals (1-2 away) and AC Milan in the 2004/05 round of 16 (0-1 away).
• United's record in three UEFA penalty shoot-outs is W1 L2:
6-5 v Chelsea, 2007/08 UEFA Champions League final
3-4 v Torpedo Moskva, 1992/93 UEFA Cup first round
4-5 v Videoton, 1984/85 UEFA Cup quarter-finals
Links and trivia
• Aside from his winner at the Camp Nou in the 1999 final, Solskjær played the first 55 minutes of United's 3-3 draw at home to Barcelona in the group stage of that season's UEFA Champions League; the Norwegian was an unused replacement as the second match at the Camp Nou also finished 3-3.
• Piqué was a Manchester United player between 2004 and 2008, making 12 Premier League appearances before returning to Barcelona.
• Alexis Sánchez made 88 Liga appearances for Barcelona between 2011 and 2014, scoring 39 times, winning the Copa del Rey in 2012 and the Liga 12 months later. He was also part of the squad that lifted the UEFA Super Cup and FIFA Club World Cup in 2011.
• Have also played in England:
Thomas Vermaelen (Arsenal 2009–14)
Philippe Coutinho (Liverpool 2013–18)
Luis Suárez (Liverpool 2011–14)
Kevin-Prince Boateng (Tottenham 2007–09, Portsmouth 2009–10)
• Coutinho's only goal in nine appearances against United for Liverpool (W3 D4 L2) came in the 2015/16 UEFA Europa League round of 16 second leg (1-1).
• Suárez scored 69 goals in 110 Premier League appearances, including two goals in his six matches against United (W2 D1 L3).
• Have also played in Spain:
David de Gea (Atlético Madrid 2008–11)
Eric Bailly (Espanyol 2013–15, Villarreal 2015–16)
Ander Herrera (Real Zaragoza 2008–11, Athletic Club 2011–14)
Juan Mata (Real Madrid Castilla 2006/07, Valencia 2007–11)
Antonio Valencia (Villarreal 2005, Recreativo Huelva 2006)
• International team-mates:
Sergi Roberto, Gerard Piqué, Jordi Alba, Sergio Busquets & David de Gea, Ander Herrera, Juan Mata (Spain)
Ousmane Dembélé, Samuel Umtiti & Paul Pogba, Anthony Martial (France)
Malcom, Rafinha, Arthur, Philippe Coutinho & Fred, Andreas Pereira (Brazil)
Lionel Messi & Sergio Romero (Argentina)
Thomas Vermaelen & Romelu Lukaku (Belgium)
Arturo Vidal & Alexis Sánchez (Chile)
• Lionel Messi has scored 22 goals in 31 matches against English clubs – more than he has managed against teams from any other country.
• Ivan Rakitić made his 100th UEFA club competition appearance in the first leg.
• Luis Suárez brought up 50 appearances in the UEFA Champions League, group stage to final, at Old Trafford. Marc-André ter Stegen will reach the same mark when he next features.
• Lionel Messi is the joint leading scorer in this season's UEFA Champions League, level with Robert Lewandowski of eliminated Bayern München on eight goals.
• Barcelona are 18 games unbeaten in all competitions (W12 D6); the 4-4 draw at Villarreal on 2 April, in which they were 4-2 down entering the 90th minute, ended a seven-match winning streak.
• A much-changed Barcelona were held 0-0 at Huesca on Saturday, the first time they have failed to score in 11 games in all competitions.
• Moussa Wagué, Jeison Murillo, Ricard Puig and Jean-Clair Todibo all made their first senior appearances for Barcelona in Saturday's stalemate.
• Barça have won their last five fixtures at the Camp Nou, where they have lost once all season, a 4-3 defeat to Real Betis on 11 November. Their record otherwise is W18 D5, with no defeats in the last 15.
• Barcelona have kept nine clean sheets in their last 14 fixtures in all competitions.
• Messi is the Liga's top scorer with 33 goals; he has 26 in his last 23 games for Barcelona and 14 in his last 13.
• Suárez has seven goals in his last ten games. Neither he nor Messi played on Saturday.
• Ousmane Dembélé had not featured since the last 16 second leg against Lyon due to a hamstring injury before playing 67 minutes on Saturday.
• Rafinha was ruled out for up to six months after tearing the anterior cruciate ligament in his left leg in the second half of the 1-1 draw with Atlético Madrid on 24 November.
• The Blaugrana, who have lifted the Copa del Rey in the last four seasons, have reached a sixth successive final and will play Valencia on 25 May at the Estadio Benito Villamarín in Seville.
• Todibo signed for Barcelona from Toulouse in January but is not in the UEFA Champions League squad; the club also agreed deals for Frenkie de Jong (Ajax) and Emerson (Atlético Mineiro) to join in the summer.
• Ashley Young made his 50th appearance in UEFA club competition in the first leg. Romelu Lukaku will reach the same mark when he next features.
• United have lost four of their last six matches, including the last three away from home. The 2-0 defeat at Arsenal on 10 March was their first in the Premier League since Ole Gunnar Solskjær replaced José Mourinho as manager on 19 December and ended a club record nine-match winning away run.
• The Red Devils were 2-1 winners against West Ham at Old Trafford on Saturday, Paul Pogba scoring both goals from the penalty spot.
• Pogba has 13 Premier League goals this season – the first time in his career he has reached double figures in a league campaign – although he had not found the net in the competition since 9 February before his weekend double.
• On 28 March Solskjær, who was initially appointed until the end of the season, was named United's permanent manager on a three-year contract.
• United's FA Cup campaign was ended by a 2-1 quarter-final defeat at Wolves on 16 March.
• Solskjær won his first eight games – the best start for a manager in United's history.
• Ander Herrera (knock) and Nemanja Matić (muscle strain) have not played since 30 March.
• Eric Bailly has not played for United since being replaced in the first half at Paris and has been struggling with concussion.
• Alexis Sánchez has been out since 2 March with a knee injury.
• Antonio Valencia (calf) and Matteo Darmian (knock) have also been sidelined.